antimitotic agent

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antimitotic agent

Oncology
An agent that inhibits cancer growth by inhibiting cell division.
 
Pharmacology
A drug that inhibits or blocks mitosis in a particular phase of the cell cycle (e.g., metaphase arrest caused by colchicine and vinca alkaloids).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

antimitotic agent

Antimicrotubule agent, mitotic inhibitor Oncology An agent that inhibits cancer growth by stopping cell division Pharmacology A drug that inhibits or blocks mitosis in a particular phase of the cell cycle–eg, metaphase arrest caused by colchicine and vinca alkaloids. See Chemotherapy.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The global breast cancer therapeutics market report estimates the market size (Revenue USD million - 2013 to 2020) for key market segments based on the drug classes - brand name (chemical name) such as antimetabolites - Gemzar (gemcitabine), aromatase inhibitors - Afinitor (everolimus), Arimidex (anastrozole), Aromasin (exemestane), Femara (leterozole), Ibrance (palbociclib); Her2 Inhibitors - Herceptin (trastuzumab), Kadcyla (ado-trastuzumab emtansine), Perjeta (pertuzumab), Tykerb (lapatinib); Hormone receptors - Fareston, Faslodex, Zoladex; and Mitotic inhibitors - Halaven (eribulin), Ixempra (ixabepilone), Taxotere (docetaxel), and forecasts growth trends (CAGR% - 2016 to 2020).
The mitotic inhibitors all contain similar cytotoxic plant alkaloids that can inhibit the polymerization of microtubules and cause metaphase arrest of mitosis, especially in rapidly dividing cells in the gastrointestinal tract and bone marrow.
Both structures were similar to the ones observed in ganglia cultured in the presence of mitotic inhibitors. Such an outgrowth was not observed from trigeminal ganglia cultured in the presence of mitotic inhibitors.
Plant alkaloids are mitotic inhibitors as they can stop mitosis or inhibit enzymes for making proteins needed for reproduction of the cell.