mitogen

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mitogen

 [mi´to-jen]
a substance that induces blast transformation; DNA, RNA, and protein synthesis; and proliferation of lymphocytes; e.g., concanavalin A, phytohemagglutinin, or lipopolysaccharide.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

mi·to·gen

(mī'tō-jen),
A substance frequently derived from plants that stimulates mitosis and lymphocyte transformation in an antigen-nonspecific manner; includes not only lectins such as phytohemagglutinins, pokeweed mitogen, and concanavalin A, but also substances from streptococci (associated with streptolysin S) and from strains of α-toxin-producing staphylococci.
Synonym(s): transforming agent (1)
[mitosis + G. -gen, producing]
Farlex Partner Medical Dictionary © Farlex 2012

mitogen

(mī′tə-jən)
n.
An agent that induces mitosis.

mi′to·gen′ic (mī′tə-jĕn′ĭk, mĭt′ə-) adj.
mi′to·ge·nic′i·ty (-jə-nĭs′ĭ-tē) n.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

mi·to·gen

(mī'tō-jen)
A substance that stimulates mitosis and lymphocyte transformation; includes not only lectins such as phytohemagglutinins and concanavalin A, but also substances from streptococci (associated with streptolysin S) and from strains of α-toxin-producing staphylococci.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

mitogen

1. Any agent that promotes cell nuclear division (MITOSIS). Mitogens are important in genetic research and technology. Pokeweed mitogen, derived from the plant Phytolacca americana , is a powerful mitogen of B LYMPHOCYTES.
2. Any substance that non-specifically causes lymphocytes to proliferate.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

mitogen

a growth factor in the form of a small protein found in blood serum that often has a specific target organ in which it induces MITOSIS.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

mi·to·gen

(mī'tō-jen)
A substance that stimulates mitosis and lymphocyte transformation; includes not only lectins such as phytohemagglutinins and concanavalin A, but also substances from streptococci and from strains of α-toxin-producing staphylococci.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Caption: FIGURE 2: Cell viability of PBMC treated with colloidal silver and mitogens. PBMC (1 x [10.sup.6] cells/mL) were treated with Con A (5 [micro]g/mL), PHA (5 [micro]g/mL), AgC (17.5 ng/mL), AgC (17.5 ng/mL) + Con A (5 [micro]g/mL), or AgC (17.5 ng/mL) + PHA (5 [micro]g/mL) and incubated for 72h at 37[degrees]C and 5% C[O.sub.2] atmosphere.
Caption: FIGURE 3: Cellular count of PBMC treated with colloidal silver and mitogens. PBMC (1 x [10.sup.6] cells/mL) were treated with Con A (5 [micro]g/mL), PHA (5 [micro]g/mL), AgC (17.5 ng/mL), AgC (17.5 ng/mL) + Con A (5 [micro]g/mL), or AgC (17.5 ng/mL) + PHA (5 [micro]g/mL) and incubated for 72 h at 37[degrees]C and 5% C[O.sub.2] atmosphere.
Complete Mitogens. Complete mitogens exhibit direct hepatotrophic effects, which is defined that they could lead DNA synthesis in serum-free media in vitro and cause liver enlargement when injected in vivo.
Auxiliary Mitogens. Auxiliary mitogens, such as bile acids (BAs) [25], norepinephrine (NE) [26], endothelial growth factor (VEGF) [27], insulin-like growth factor system (IGF system) [28], estrogen [29], and serotonin [30] (Table 1), although not mitogenic in cultured hepatocytes, may delay liver regeneration in their absence.
We tested proliferation by adding 0.5 [micro]Ci [sup.3]H-thymidine (ICN Biomedical, Irvine, CA) in a volume of 100 [micro]L to each well after a 4-day incubation (96 hr) or a 5-day incubation (120 hr) with mitogens. Plates were further incubated for an additional 16 hr and then harvested onto Unifilter plates (Packard, Meridian, CT) using a Packard Filtermate 96-well plate harvester.
(Fabaceae) on mitogen response of the spleen cells in Graffi tumor bearing (GTBH) and healthy hamsters were reported.
Lowered mitogen-induced lymphoproliferative activities indicate that both T and B cells are less responsive to stimulation by particular mitogens and, therefore, suggest that they are less able to initiate or augment an immune response to foreign agents.
After mitogen stimulation of the spleen cells, 20 [micro]l/well of tetrazolium salt MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide, Siga, St.
Therefore, the current study was conducted to determine the effects of SDG on mitogen stimulated human lymphocyte proliferation in vitro.
The studies described in this article concern a mitogenic agent isolated from ground corncob animal bedding (corn mitogen; CM), from commercially available fresh corn (kernels or cob), or from corn tortillas which blocks male and female reproductive behavior and also causes persistent metestrus in adult female rats.