mitogen

(redirected from Mitogens)
Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to Mitogens: mitogenesis

mitogen

 [mi´to-jen]
a substance that induces blast transformation; DNA, RNA, and protein synthesis; and proliferation of lymphocytes; e.g., concanavalin A, phytohemagglutinin, or lipopolysaccharide.

mi·to·gen

(mī'tō-jen),
A substance frequently derived from plants that stimulates mitosis and lymphocyte transformation in an antigen-nonspecific manner; includes not only lectins such as phytohemagglutinins, pokeweed mitogen, and concanavalin A, but also substances from streptococci (associated with streptolysin S) and from strains of α-toxin-producing staphylococci.
Synonym(s): transforming agent (1)
[mitosis + G. -gen, producing]

mitogen

(mī′tə-jən)
n.
An agent that induces mitosis.

mi′to·gen′ic (mī′tə-jĕn′ĭk, mĭt′ə-) adj.
mi′to·ge·nic′i·ty (-jə-nĭs′ĭ-tē) n.

mi·to·gen

(mī'tō-jen)
A substance that stimulates mitosis and lymphocyte transformation; includes not only lectins such as phytohemagglutinins and concanavalin A, but also substances from streptococci (associated with streptolysin S) and from strains of α-toxin-producing staphylococci.

mitogen

1. Any agent that promotes cell nuclear division (MITOSIS). Mitogens are important in genetic research and technology. Pokeweed mitogen, derived from the plant Phytolacca americana , is a powerful mitogen of B LYMPHOCYTES.
2. Any substance that non-specifically causes lymphocytes to proliferate.

mitogen

a growth factor in the form of a small protein found in blood serum that often has a specific target organ in which it induces MITOSIS.

mi·to·gen

(mī'tō-jen)
A substance that stimulates mitosis and lymphocyte transformation; includes not only lectins such as phytohemagglutinins and concanavalin A, but also substances from streptococci and from strains of α-toxin-producing staphylococci.
References in periodicals archive ?
Caption: FIGURE 2: Cell viability of PBMC treated with colloidal silver and mitogens. PBMC (1 x [10.sup.6] cells/mL) were treated with Con A (5 [micro]g/mL), PHA (5 [micro]g/mL), AgC (17.5 ng/mL), AgC (17.5 ng/mL) + Con A (5 [micro]g/mL), or AgC (17.5 ng/mL) + PHA (5 [micro]g/mL) and incubated for 72h at 37[degrees]C and 5% C[O.sub.2] atmosphere.
Caption: FIGURE 3: Cellular count of PBMC treated with colloidal silver and mitogens. PBMC (1 x [10.sup.6] cells/mL) were treated with Con A (5 [micro]g/mL), PHA (5 [micro]g/mL), AgC (17.5 ng/mL), AgC (17.5 ng/mL) + Con A (5 [micro]g/mL), or AgC (17.5 ng/mL) + PHA (5 [micro]g/mL) and incubated for 72 h at 37[degrees]C and 5% C[O.sub.2] atmosphere.
Complete Mitogens. Complete mitogens exhibit direct hepatotrophic effects, which is defined that they could lead DNA synthesis in serum-free media in vitro and cause liver enlargement when injected in vivo.
Auxiliary Mitogens. Auxiliary mitogens, such as bile acids (BAs) [25], norepinephrine (NE) [26], endothelial growth factor (VEGF) [27], insulin-like growth factor system (IGF system) [28], estrogen [29], and serotonin [30] (Table 1), although not mitogenic in cultured hepatocytes, may delay liver regeneration in their absence.
Figure 2 summarized the measurement of tumor necrosis factor alpha (TNF-[alpha]) levels in unstimulated (left), T-cell mitogen stimulated (center, phytohaemmaglutinin, PHA), and T-dependent B-cell mitogen (right, pokeweed, PWM) stimulated cell cultures.
Magnitude of response of peripheral blood lymphocytes to synthesizes DNA and incorporate [[.sup.3.H]]-thymidine upon in vitro stimulation with mitogen/antigen declined in order: mitogen phytohaemagglutinin (PHA) > concanavalin A (ConA) > antigen CD3 (CD3) > pokeweed mitogen (PWM).
We tested proliferation by adding 0.5 [micro]Ci [sup.3]H-thymidine (ICN Biomedical, Irvine, CA) in a volume of 100 [micro]L to each well after a 4-day incubation (96 hr) or a 5-day incubation (120 hr) with mitogens. Plates were further incubated for an additional 16 hr and then harvested onto Unifilter plates (Packard, Meridian, CT) using a Packard Filtermate 96-well plate harvester.
(Fabaceae) on mitogen response of the spleen cells in Graffi tumor bearing (GTBH) and healthy hamsters were reported.
Lowered mitogen-induced lymphoproliferative activities indicate that both T and B cells are less responsive to stimulation by particular mitogens and, therefore, suggest that they are less able to initiate or augment an immune response to foreign agents.
After mitogen stimulation of the spleen cells, 20 [micro]l/well of tetrazolium salt MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide, Siga, St.
Therefore, the current study was conducted to determine the effects of SDG on mitogen stimulated human lymphocyte proliferation in vitro.
The studies described in this article concern a mitogenic agent isolated from ground corncob animal bedding (corn mitogen; CM), from commercially available fresh corn (kernels or cob), or from corn tortillas which blocks male and female reproductive behavior and also causes persistent metestrus in adult female rats.