DUSP1

(redirected from Mitogen-activated protein kinase phosphatase 1)

DUSP1

A gene on chromosome 5q34 that encodes dual-specificity phosphatase 1, a protein which dephosphorylates MAP kinase MAPK1/ERK2. DUSP1 downregulates cell proliferation and is thought to play a key role in cellular responses to environmental stress. It is also a less preferred gene symbol for what is now designated as DUSP12, see there.
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Thus, we investigated the effects of GLCCI1 deficiency on the GC sensitivity in asthmatic mice model and detected the glucocorticoid receptor (GR), mitogen-activated protein kinase phosphatase 1 (MKP-1) expression, and p38 mitogen-activated protein kinase (MAPK) phosphorylation level in the lung tissue of these mice.

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