mitogen-activated protein kinase

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MAP kinase

Any of a family of serine/threonine protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group, which are involved in cellular responses to various stimuli (e.g., mitogens, osmotic stress, heat shock and cytokines) and regulate cell growth, cycling, differentiation, mitosis and apoptosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

mitogen-activated protein kinase



A signaling protein, i.e., a protein that circulates extracellularly influencing other cells to turn on the process of protein synthesis. These proteins have an effect on cellular replication and cellular death in inflammatory, ischemic, and malignant diseases.

mitogen-activated protein kinase

Abbreviation: MAPK
A signaling enzyme, i.e., one that circulates extracellularly, influencing cells to begin protein manufacturing. They affect cellular replication and death in inflammatory, ischemic, and malignant diseases.
See also: protein kinase
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
TLRs have also been shown to be involved in the abnormal renal function in several diseases like tuberculosis, salmonellosis, and rheumatoid arthritis, but their role is largely unknown in visceral leishmaniasis.4 TLRs signaling occur via MyD88 dependent or independent pathways that lead to the activation of either p38 or ERK1/2 related mitogen activated protein kinases (MAPK) and subsequent production of either inflammatory cytokines such as TNF-[alpha], IFN-[gamma], and IL-12 or anti-inflammatory cytokines such as IL-4, IL-10.5 Many studies also suggest the importance of TLRs signaling in the onset of leishmanial pathogenesis, resistance and susceptibility; however, limited data exist on their expression in the kidney and their role in renal damage in L.
Abbreviations COX-2: Cyclooxygenase-2 GM-CSF: Granulocyte-macrophage colony stimulating factor IKK or I[kappa]B kinase: Inhibitory nuclear factor kappa-B kinase IL-1[beta]: Interleukin-1[beta] IL-6: Interleukin-6 iNOS: Inducible nitric oxide synthase MAPKs: Mitogen activated protein kinases NF-[kappa]B: Nuclear factor kappa-B NO: Nitric oxide [PGE.sub.2]: Prostaglandin [E.sub.2] PI3K: Phosphatidylinositol 3-phosphate PKB/Akt: Protein kinase B RT-PCR: Reverse transcription PCR TNF-[alpha]: Tumor necrosis factor-[alpha] TAK1: TGF[beta]-activated kinase 1 TAB1/2: TGF[beta]-activated kinase 1 bind proteins 1 and 2.
The cascade of signal transduction events leading to the translocation and trafficking of GLUT4 molecules in response to insulin is mediated by a host of proteins collectively known as the mitogen activated protein kinases (MAPKs).
Similarly, one can imagine autoactivating antibodies that preferentially activate downstream pathways, such as MAPK (mitogen activated protein kinase) growth pathways but not cAMP signaling.
Recent study reported that eotaxin could activate extracellular signal regulated kinase 2 (ERK2) and p38 mitogen activated protein kinase (MAPK) to stimulate the migration of eosinphils to epithelial cells, then activate, produce and release several inflammatory mediators to induce airway inflammation.13 In addition, the elevated eotaxin levels were also observed in allergicrhinitis.14 All these above suggested that IL-17 and eotaxin play a critical role in asthma and allergic rhinitis.
Cheng, "TGF-[beta] regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study," Endocrinology, vol.
It is an oral brain penetrant, which is highly selective and a potent inhibitor of the alpha isoform of the protein enzyme p38 mitogen activated protein kinase (p38 MAPK alpha).
The aim of the present study was to explore the potential cytotoxic activity of tanapsin on human tumor cells and its underlying mechanisms of cell death, including the activation of the caspase cascade, the mitogen activated protein kinase pathway, the changes in the expression of the Bcl-2 family proteins, as well as the disruption of mitochondrial membrane potential and accumulation of intracellular reactive oxygen species.
Zhang, "Evolutionary history of the vertebrate mitogen activated protein kinases family," PLoS ONE, vol.
Gaestel et al., "P38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level," Biochemical and Biophysical Research Communications, vol.

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