TFAM(redirected from Mitochondrial transcription factor 1)
TFAMA gene on chromosome 10q21 that encodes a transcription factor which activates mitochondrial transcription and participates in mitochondrial genome replication. TFAM is required for regulating mitochondrial genome copy number and for embryonic development.
Targeted disruption of TFAM expression in mice results in physiological model of Kearns-Sayre syndrome.
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