cytochrome c oxidase

(redirected from Mitochondrial complex IV)

cy·to·chrome c ox·i·dase

(sī'tō-krōm oks'i-dās),
A cupriferous cytochrome of the a type that catalyzes the oxidation of four molecules of ferrocytochrome c by molecular oxygen to produce four molecules of ferricytochrome c and 2H2O. A part of Complex IV of the respiratory chain. A deficiency of one or more of the polypeptides of this complex results in neuronal loss in the brain leading to psychomotor retardation and neurodegenerative disease.
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2] tension (hypoxia), inhibition of mitochondrial complex IV by NO can be severe and persistent [29, 45, 46].
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