TFAM

(redirected from Mitochondrial Transcription Factor A)
Also found in: Acronyms.

TFAM

A gene on chromosome 10q21 that encodes a transcription factor which activates mitochondrial transcription and participates in mitochondrial genome replication. TFAM is required for regulating mitochondrial genome copy number and for embryonic development.

Molecular pathology
Targeted disruption of TFAM expression in mice results in physiological model of Kearns-Sayre syndrome.
References in periodicals archive ?
Jimenez-Menendez et al., "Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter," Nature Structural & Molecular Biology, vol.
Clayton, "Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion," Biochemical and Biophysical Research Communications, vol.
Rantanen et al., "Mitochondrial transcription factor A regulates mtDNA copy number in mammals," Human Molecular Genetics, vol.
Hood, "The regulation of mitochondrial transcription factor A (Tfam) expression during skeletal muscle cell differentiation," Bioscience Reports, vol.
Broekmans et al., "Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A," Nature Communications, vol.
Kaufman, "Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number," Biochimica et Biophysica Acta, vol.
Endo, "Interaction of human mitochondrial transcription factor A in mitochondria: its involvement in the dynamics of mitochondrial DNA nucleoids," Genes to Cells, vol.
LonP1, mitochondrial AAA protease; mtDNA, mitochondrial DNA; TFAM, mitochondrial transcription factor A.
Lezza, "Mitochondrial transcription factor A (TFAM): one actor for different roles," Frontiers in Biology, vol.
Alonso-Montes et al., "Mitochondrial transcription factor a (TFAM) gene variation and risk of late-onset Alzheimer's disease," Journal of Alzheimer's Disease, vol.
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