mitochondrial DNA

(redirected from Mitochondrial DNA copy number)
Also found in: Dictionary.
Related to Mitochondrial DNA copy number: Mitochondria DNA

mitochondrial DNA (mtDNA),

species of DNA present in mitochondria, where it participates in energy metabolism, rather than in the nucleus.

mitochondrial DNA

n. Abbr. mtDNA
DNA that is contained in the mitochondria of eukaryotic cells and is inherited maternally.

mitochondrial DNA

A small circular DNA molecule of which all MITOCHONDRIA in cells have several copies. It contains 16,569 base pairs and 37 genes. Being present in the cytoplasm of the cell, is transmitted exclusively by the mother. A mature ovum contains about 100,000 copies of mitochondrial DNA; sperms contain none. The genome has been completely sequenced. Its main function is to code for enzymes needed by the mitochondrion. The sites of common mutations, especially deletions, are known as are a number of diseases caused by these defects in the mitochondrial DNA. See MITOCHONDRIAL DNA DISEASES.

mitochondrial DNA (mtDNA)

the DNA GENOME in the MITOCHONDRION that codes for a number of the organelle's functions. The genome is replicated and transcribed by a separate set of ENZYMES from those of the eukaryotic cell NUCLEUS. In METAZOANS the mtDNA is generally circular, and there appear to be no INTRONS. The GENETIC CODE shows differences from the universal code.
References in periodicals archive ?
Hsieh, "Maintenance of mitochondrial DNA copy number and expression are essential for preservation of mitochondrial function and cell growth," Journal of Cellular Biochemistry, vol.
The relationship between leukocyte mitochondrial DNA copy number and telomere length in community-dwelling elderly women.
In a Korean study, an inverse relationship was reported between peripheral mitochondrial DNA copy number and visceral fat mass [18].
Nagley, "Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age," Nucleic Acids Research, vol.
The implications of mitochondrial DNA copy number regulation during embryogenesis.
Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients.
Mitochondrial DNA copy number reflects the extent of mitochondrial biogenesis, whose variations can be better appreciated at later differentiation times (i.e., DifD3).
210) investigated whether low-level benzene exposure was associated with increased blood mitochondrial DNA copy number (mtDNAcn), a biological oxidative response to mitochondrial DNA damage and dysfunction, and they examined potential links between mtDNAcn and leukemia-related epigenetic markers.
Mitochondrial DNA copy number was normalized to nuclear DNA copy number by amplification of the acidic ribosomal phosphoprotein P0 (Arbp/36B4) nuclear gene.
OBJECTIVES: Our goals were to determine in a large multicenter cross-sectional study whether low-level benzene is associated with increased blood mitochondrial DNA copy number (mtDNAcn, a biological oxidative response to mitochondrial DNA damage and dysfunction) and to explore potential links between mtDNAcn and leukemia-related epigenetic markers.
Gene Expression and Mitochondrial DNA Copy Number. Total liver and fibroblast DNA was isolated with solvent extraction as described elsewhere [31].
In parallel with the alteration of cellular phenotype, mitochondrial damage also occurred in the tubular cells as evidenced by the altered mitochondrial morphology, reduced MMP and mitochondrial DNA copy number, and increased ROS production.

Full browser ?