TABLE 2 Traditional vs nontraditional dosing * (31) Combination Oral pills Placebos Other pills (No.) contraceptive (No.) (No.) Traditional OCP 21 7 0 Femcon Fe ([dagger]) 21 7 0 Mircette
21 2 5 (10 mcg EE) Natazia 22 2 2 (3 mg EV); 2 (1 mg EV) Lo Loestrin FE 24 0 2 (10 mcg EE); 2 (75 mg ferrous fumarate) Yaz 24 4 0 Seasonique 84 0 7 (10 mcg EE) Lybrel 365 0 0 * A partial list.
(The ring uses a related compound.) These pills (brands such as Desogen, Mircette
, and Cyclessa) were developed in the 1980s to lessen the pill's minor side effects, like acne and facial hair.
In addition, the company announced that it has received regulatory clearance for generic Mircette
(Duramed Pharmaceuticals Inc.).
Such low-dose estrogen products include Ortho Tri-Cyclen Lo from Johnson & Johnson's (New Brunswick NJ) Ortho-McNeil unit, Barr Pharmaceuticals Inc.'s (Woodcliff Lake NJ) Mircette
, and Yaz, from Bayer AG's Berlex.
Lay gave the example of Mircette, which contains 21 days of 0.15-mg desogestrel/0.02-mg ethinyl estradiol, followed by 2 days of placebo pills and 5 days of 0.01-mg ethinyl estradiol.
"It's not whether the estrogen is present or absent, but [it's] the change in estrogen and I find many patients don't do well on Mircette because of fluctuations in estrogen."
Lay gave the example of Mircette, which contains 21 days of 0.15 mg desogestrel/0.02 mg ethinyl estradiol, followed by 2 days of placebo pills and 5 days of 0.01 mg ethinyl estradiol.
who put patients on Mircette because they think it might help menstrually related migraines," she said.
(5.) Shortened pill-free interval delivered by new 20 mcg pill, Organon's Mircette
, schedule for US debut this summer.
The third-generation progestins--norgestimate (OrthoCyclen, Ortho Tri-Cyclen) and desogestrel (Desogen, OrthoCept, Mircette
)--are less likely to cross-react with androgen receptors.
Barr says Kariva is the generic equivalent to Organon Inc.'s Mircette
The company's Mircette
(desogestrel/ethinyl estradiol and ethinyl estradiol) oral contraceptive tablets feature a patented dosing regimen.