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formation of or conversion into bone or a bony substance.
ectopic ossification a pathological condition in which bone arises in tissues not in the osseous system and in connective tissues usually not manifesting osteogenic properties.
endochondral ossification ossification that occurs in and replaces cartilage.
heterotrophic ossification metaplastic ossification.
intramembranous ossification ossification of bone that occurs in and replaces connective tissue.
metaplastic ossification the development of bony substance in normally soft body structures; called also heterotrophic ossification.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


1. The formation of bone.
2. A change into bone.
[L. ossificatio, fr. os, bone, + facio, to make]
Farlex Partner Medical Dictionary © Farlex 2012


1. The natural process of bone formation.
a. The hardening or calcification of soft tissue into a bonelike material.
b. A mass or deposit of such material.
a. The process of becoming set in a rigidly conventional pattern, as of behavior, habits, or beliefs.
b. Rigid, unimaginative convention.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


1. The formation of bone.
2. A change into bone.
[L. ossificatio, fr. os, bone, + facio, to make]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


(os?i-fi-ka'shun) [? + facere, to make]
1. The formation of bone matrix.
2. The replacement of other tissue by bone, esp. during fetal development. See: osteogenesis
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ENDOCHONDRAL OSSIFICATION: Ossification process in a long bone; (A) progression from embryo to young adult, (B) microscopic view of an epiphyseal disk
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endochondral ossification

The formation of bone in cartilage, as in the formation of long bones, involving the destruction and removal of cartilage and the formation of osseous tissue in the space formerly occupied by the cartilage. See: illustration

intramembranous ossification

The formation of bone in or underneath a fibrous membrane, such as occurs in the formation of the cranial bones.

pathologic ossification

The formation of bone in abnormal sites or abnormal development of bone.

periosteal ossification

The formation of successive thin layers of bone by osteoblasts between the underlying bone or cartilage and the cellular and fibrous layer that covers the forming bone. Also called subperiosteal ossification.
Medical Dictionary, © 2009 Farlex and Partners


The process of conversion of other tissues into bone. Most bone forms from CARTILAGE but some is laid down by other connective tissue (membranous bone). Ossification may also occur in tissues that have been the site of disease such as long-term inflammation.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005


bone formation which replaces another structure such as cartilage.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005


1. The formation of bone.
2. A change into bone.
[L. ossificatio, fr. os, bone, + facio, to make]
Medical Dictionary for the Dental Professions © Farlex 2012

Patient discussion about ossification

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More discussions about ossification
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References in periodicals archive ?
Inozyme Pharma is a biotechnology company focused on developing novel medicines for the treatment of rare diseases characterized by mineral imbalances, which lead to over calcification of soft tissues and under mineralization of bone.
Initiation and progression of mineralization of bone nodules formed in vitro: the role of alkaline phosphatase and organic phosphate.
Maternal diabetes mellitus influences the developing teeth of the embryo or premature children, with reduced mineralization of bone found to be more common in the children of diabetic mothers compared with controls [Grahnen and Edlund, 1968; Noren, 1984; Seow and Perham, 1990; Schwartz, 2003; Carnevale et al., 2004].
Runt-related transcription factor 2/core binding factor al (Runx2/Cbfa 1 ) and osterix (Osx) are key transcription factors participating in activation of osteogenic differentiation of mesenchymal pluripotent cells and crucial for the regulation of genes responsible for the production of bone specific matrix proteins such as type 1 collagen (Col-I), osteocalcin (OCN) and bone sialoprotein (BSP) and eventually stimulates mineralization of bone nodules (Duty et al.
[10.] Tenenbaum H.C., "Role of organic phosphate in mineralization of bone in vitro", J.
Pan et al described that the pheno-typic markers of osteoblast proliferation and differentiation appear in the following order: cell growth and proliferation, production of ALP and NO, and lastly mineralization of bone nodules (Pan et al.
Zinc is very essential element for growth of tissues healing of wounds maintenance of connective tissues functioning of immune system mineralization of bones blood clotting and sperm production.
Nutritional status and somatic development in these patients are closely connected with mineralization of bones. Lowered quality of life in this chronic disease, limited physical activity (frequent hospitalizations, physiotherapy procedures), inhaled and systemic steroid therapy and finally impaired absorption impact the calcification of bones [6,7].
Rickets is a common preventable disease that leads to the under mineralization of bones and subsequently multiple bone deformities.