KCNE2

(redirected from MinK-related peptide 1)

KCNE2

A gene on chromosome 21q22.12 that encodes a member of the voltage-gated, isk-related potassium channel subfamily; it is a small-membrane subunit, which assembles with the KCNH2 protein product, a pore-forming protein, and is expressed in heart and muscle.

Molecular pathology
KCNE2 mutations are associated with arrhythmias.
References in periodicals archive ?
More recently, a sixth gene, the minK-related peptide 1 (MiRP1), localized to 21q22 as well (Figure 2), was identified.[30] Several other families with autosomal-dominant LQTS are not linked to any known LQTS loci, indicating the existence of additional LQTS-causing genes.
MiRP1, the minK-related peptide 1, or KCNE2, is a novel potassium channel gene recently cloned and characterized by Abbott and colleagues.[30] MiRP1 is a 123-amino-acid channel protein with a single predicted transmembrane segment similar to that described for minK.[34] Chromosomal localization studies mapped this KCNE2 gene to chromosome 21q22.1 (Figure 2), within 79 kb of KCNE1 (minK) and arrayed in opposite orientation.[30] The open reading frames of these 2 genes share 34% identity, and both are contained in a single exon, suggesting that they are related through gene duplication and divergent evolution.