Mikulicz

Mi·ku·licz

(mē'kū-lich),
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Masks were first introduced in Germany in 1897 in response to high levels of wound infections caused by Haemolytic streptococcus --the resultant decrease in wound infections was reported by Mikulicz (1897).
[4] HIV associated salivary gland disease, hepatitis C virus associated sialadenitis, drug associated salivary gland disease, granulomatous sialadenitis, nonspecific reactive changes, necrotizing sialometaplasia, Sjogren's syndrome and Mikulicz syndrome are other non- neoplastic salivary gland lesions.
(1) The disease has classic histopathologic features consisting of Mikulicz cells, Russell bodies, and gram-negative bacilli.
The main diseases that should be excluded are some malign diseases such as lymphoma, Kaposi's sarcoma, angiosarcoma, neck metastasis of malign tumors, dermatofibrosarcoma protuberance, cylindroma as well as some benign conditions such as hemangioma, pyogenic granuloma, Kikuchi disease, Mikulicz disease, angioimmunoblastic lymphadenopathy, ESAH and parasite diseases such as toxoplasmosis that may also cause increases in serum IgE levels and blood eosinophil counts (2-4,8,11).
Mikulicz's disease, which consists of symmetrical swelling of the lacrimal and salivary glands, is now recognized as IgG4-related dacryoadenitis and IgG4-related sialoadenitis (IgG4-RS) (6).
The common lesions being enlargement or inflammation (sclerosing sialadenitis-formerly termed Mikulicz disease and Kuttner's tumor).
Small ulcers (minor type) (Mikulicz) are smaller than 1 cm in diameter (usually 2-5 mm) and can heal rapidly within 4-14 days.
Diseases such as Riedel thyroiditis, Mikulicz disease, Kuttner tumor, idiopathic orbital inflammation (inflammatory pseudotumor), orbital lymphoid hyperplasia, and pituitary hypophysitis are examples of some of the previously classified diseases that have been added to the spectrum of IgG4-RD (3).
She was diagnosed to have Mikulicz syndrome and started on steroid and azathioprine.
Common manifestations include type I autoimmune pancreatitis (AIP), swelling of salivary and lacrimal glands (Mikulicz's disease), retroperitoneal fibrosis, and lymphadenopathy.