MTTP

(redirected from Microsomal Triglyceride Transfer Protein)
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MTTP

A gene on 4q24, which encodes a large subunit of the heterodimeric microsomal triglyceride transfer protein which, with protein disulphide isomerase, completes the heterodimeric microsomal triglyceride transfer protein, which plays a central role in lipoprotein assembly.

References in periodicals archive ?

Barral et al., "Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function," The Journal of Clinical Investigation, vol.

CDl-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity

Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia.

Measurement of fractional synthetic rates of multiple protein analytes by triple quadrupole mass spectrometry

Those cholesterol-reducing drugs that followed statins were cholesteryl ester transporter protein (CETP) inhibitors, Niemann-Pick Cl-like 1 (NPC1L1) inhibitors, microsomal triglyceride transfer protein (MTTP) inhibitors, and acyl-CoA cholesterol acyltransferase (ACAT) inhibitors.

New idol for cholesterol reduction?

Abetalipoproteinemia (ABL; OMIM 200100) is a very rare autosomal recessive disorder of lipoprotein metabolism in which sequence variations in the microsomal triglyceride transfer protein (MTP) gene lead to virtually undetectable plasma concentrations of apoB-containing lipoproteins.

Assessment of tocopherol metabolism and oxidative stress in familial hypobetalipoproteinemia

It is this domain with which microsomal triglyceride transfer protein (MTP) binds during apoB assembly.

Lipid disorders and mutations in the APOB gene

Hepatic and intestinal steatosis occur both in a-[beta]-lipoproteinemia (reflecting mutation of the microsomal triglyceride transfer protein, which allows apo B to associate physically with triglycerides in the liver and gut) and in homozygous hypo-[beta]-lipoproteinemia when mutations truncate apo B early in its sequence (2).

Can measurement of apolipoprotein B replace the lipid profile in the follow-up of patients with lipoprotein disorders?