microcystin

(redirected from Microcystine)

microcystin

(mī-krō-sis'tin),
Those compounds produced by Microcystis aeruginosa: potent hepatotoxins and probable tumor promoters.

microcystin

Any toxic, cyclic, non-ribosomal peptide produced by cyanobacteria, which has anticholinesterase activity or causes severe liver injury through DNA damage by activating endonucleases and inhibiting inhibit protein phosphatases types 1 and 2A. Topical exposure to microcystins causes skin and eye irritation, rhinorrhoea, vertigo and fatigue; parenteral exposure may cause death after initial exposure, often due to intrahepatic haemorrhage and hypovolemic shock. An epidemic of microcystin-related death occurred at a haemodialysis centre in Brazil due to impure water.
References in periodicals archive ?
Biochemical characterization and inhibitory effects of dinophysistoxin-1, okadaic acid and microcystine LR on protein phosphatase 2A purified from the mussel Mytilus chilensis.
Furthermore, injuries found in the liver and kidney of the birds days later showed the toxic action of microcystine. Although assessed total microcystines concentration was low, Chl-a concentration during the peak of mortality was much higher, revealing that toxicity may vary in the same strain, in the same water body and even during the same bloom (De Leon, 2002).
The most usually detected hepatotoxin is microcystine, which acts as an inhibitor of protein phosphatase 1 and 2A (Chorus and Bartram, 1999).
Samples were taken in order to identify algal species, Chl-a concentration (spectrophotometry) and toxins-total microcystines (inmuno-enzymatic assay, ELISA).
Maximal value of total microcystines concentration was 0.23 [micro]g.[L.sup.-1].