microarray

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microarray

(mī′krō-ə-rā′)

microarray

An array of hundreds or thousands of spots containing specific oligonucleotides, cDNAs, proteins, peptides or other small molecules chemically attached to a substrate and organised in a grid on a glass or plastic slide, silicon chip, fibre-optic array or filter membrane. The microarray is bathed with probes to analyse gene expression by hybridisation, and it is used to detect changes in gene expression by comparing radioactively or chemically labelled cDNA prepared from the total mRNA of an experimental sample to that of a control sample. The relative intensity of the signal corresponding to each spot in the microarray reveals whether the expression of a particular gene is increased, decreased or unchanged.

microarray

A collection on a chip of thousands of biological probes such as DNA single-strand sequences, protein-detecting molecules, or any other biologically-identifying material, that can be used to survey a specimen for the presence of a target gene or substance. Binding to the target substance can be made to cause fluorescence to occur at the unique spot or spots on the array and the chip can then be read by a scanner and the result displayed on a computer monitor. See also DNA MICROARRAYS.

microarray

see DNA MICROARRAY.
References in periodicals archive ?
The global microarray analysis market is marked by the presence of eminent players such as Thermo Fisher Scientific, Gyros AB, Luminex Corporation, NextGen Sciences PLC, Biomerieux SA, ProteoGenix, Affymetrix Inc., Sequenom Inc., Discerna, Illumnia Inc., Applied Microarrays, Agilent Technologies Inc., and Roche NimbleGen.
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Arrayit has been selling its patented microarray technology since 1997.
The remainder of this review covers the current progress in the use of protein microarrays for biomarker discovery and validation, reviews their use in in vitro diagnostics, and discusses the use of protein microarrays in the field of personalized medicine.
Protein microarrays are an emerging market opportunity as a result of continuing advances in proteomics to understand gene function and diseases.
Los microarrays de productos de PCR o Spotted Microarrays estan formados por sondas (spots) sintetizadas previamente y depositadas en la superficie del microarray mediante un robot (microarray spotter).
For now though, companies like Illumina and Affymetrix will continue rapid-fire development of "bigger and better" microarrays, believing, as Bornstein says, that "there's an ongoing need for content to be developed so the research community can meet its research needs.
The Microarrays MediaBook is an example of where education needs to be today and in the future.
SciTech21-5 December 2006-Baylor College of Medicine Obtains License from Affymetrix for Microarray Patents(C)2006 JeraOne - http://www.jeraone.com
Microarrays are a high throughput technology that allows for the analysis of hundreds to thousands of genes simultaneously.
The research will use Orion's proprietary DNA methylation technologies, including MethylScope(r) microarrays and MethylScreen(r) PCR assays.
Next came DNA microarrays that measured thousands of genes simultaneously.