microarray

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microarray

(mī′krō-ə-rā′)

microarray

An array of hundreds or thousands of spots containing specific oligonucleotides, cDNAs, proteins, peptides or other small molecules chemically attached to a substrate and organised in a grid on a glass or plastic slide, silicon chip, fibre-optic array or filter membrane. The microarray is bathed with probes to analyse gene expression by hybridisation, and it is used to detect changes in gene expression by comparing radioactively or chemically labelled cDNA prepared from the total mRNA of an experimental sample to that of a control sample. The relative intensity of the signal corresponding to each spot in the microarray reveals whether the expression of a particular gene is increased, decreased or unchanged.

microarray

A collection on a chip of thousands of biological probes such as DNA single-strand sequences, protein-detecting molecules, or any other biologically-identifying material, that can be used to survey a specimen for the presence of a target gene or substance. Binding to the target substance can be made to cause fluorescence to occur at the unique spot or spots on the array and the chip can then be read by a scanner and the result displayed on a computer monitor. See also DNA MICROARRAYS.

microarray

see DNA MICROARRAY.
References in periodicals archive ?
Information retrieval, data mining, the development of tools for mining data, and database development are now critical issues for the effective use of microarray technology.
Application of complementary DNA microarray technology to carcinogen identification, toxicology, and drug safety evaluation.
Pasternak (University of Waterloo, Canada) updates this second edition of the text with the latest developments in functional genomics, proteomics, and microarray technology. Coverage progresses from fundamentals of cytogenetics and Mendelian genetics through techniques for gene manipulation and mapping and the molecular genetics of distinct biological systems.
With its expertise in closely related areas such as toxicology, exposure assessment, and microarray technology, the NIEHS has been at the forefront of toxicogenomics.
Corning, NY 10/18/01--As part of its third quarter results earnings release, Corning Incorported announced it is discontinuing its initiative in Corning Microarray Technology products.
Microarray technology enables researchers to measure the transcription of multitudes of genes simultaneously on tiny microchips containing thousands of targets of complementary DNA (cDNA) or synthetic DNA segments (oligonucleotides) immobilized in a preset arrangement.
Vysis' fluorescence in situ Hybridization (FISH) DNA probe technology utilizes microarray technology and will be useful for both clinical diagnostics and R&D.
"This mainly reflects the advanced state of DNA-based microarray technology," says Kenneth Ramos, a professor of toxicology at Texas A&M University and the editor of EHP Toxicogenomics Edition, a new quarterly edition of EHP debuting in 2003.
Also, the Applied Research Centre for Genomic Technology has applied microarray technology to Chinese medicines and a Chinese medicine project is also underway at the ASTRI.
For example, the advent of microarray technology means researchers can look at the expression of a variety of genes simultaneously.
diaDexus will use Agilent's customizable microarray technology for research in causes of disease ...
Powerful new analytical methodologies, including microarray technology and nanotechnology, are providing novel approaches to investigate these issues.