microarray


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Related to microarray: Microarray analysis, Protein microarray

microarray

(mī′krō-ə-rā′)

microarray

An array of hundreds or thousands of spots containing specific oligonucleotides, cDNAs, proteins, peptides or other small molecules chemically attached to a substrate and organised in a grid on a glass or plastic slide, silicon chip, fibre-optic array or filter membrane. The microarray is bathed with probes to analyse gene expression by hybridisation, and it is used to detect changes in gene expression by comparing radioactively or chemically labelled cDNA prepared from the total mRNA of an experimental sample to that of a control sample. The relative intensity of the signal corresponding to each spot in the microarray reveals whether the expression of a particular gene is increased, decreased or unchanged.

microarray

A collection on a chip of thousands of biological probes such as DNA single-strand sequences, protein-detecting molecules, or any other biologically-identifying material, that can be used to survey a specimen for the presence of a target gene or substance. Binding to the target substance can be made to cause fluorescence to occur at the unique spot or spots on the array and the chip can then be read by a scanner and the result displayed on a computer monitor. See also DNA MICROARRAYS.

microarray

see DNA MICROARRAY.
References in periodicals archive ?
Microarray analysis has garnered many accolades from the medical field due to the inherent advantages associated with it such as faster diagnosis, flexibility, economic benefits, accuracy, and others.
Microarray data gathered by fabrication, hybridization and image processing.
It also includes various microarray technologies used in research, drug development, and diagnostics.
The availability of Agilent SurePrint human, mouse and rat miRNA microarrays, with miRBase 21 targets, provides pre-designed microarrays for the most commonly studied models.
The guidelines proposed in MIAME/plant are the base of the current proposed data format for Microarray Gene Expression Data.
For children presenting with a suspected syndrome, problems with growth, or a development or autism spectrum disorder, microarray is "really our go-to test right now," said Dr.
Microarray analysis, paired with karyotyping, can elucidate ultrasound-identified fetal anomalies
Scienion, providing microarray printing development, microarray production systems and contract microarray print and development services to the life sciences industry, had revenues of CAD5m and EBITDA of around CAD400,000 last year.
This resource for microarray researchers and computer scientists brings together the fields of image processing, data analysis, and molecular biology.
The researchers compared the findings from three clinical genetic tests: G-banded karyotype and fragile X testing, the current standard battery of genetic testing, and chromosomal microarray analysis, for which testing guidelines have not yet been established.
The other assay format, the reversed-phase protein microarray (RPPM), consists of a multitude of different samples, such as tissue or cell lysates, that are immobilized as spots in rows on a solid support.
Eden Prairie, MN 9/30/08--SurModics, a surface modification and drug delivery technologies company, has acquired GE Healthcare's CodeLink Activated Slide microarray business.