microRNA


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microRNA

(mī′krō-är′ĕn′ā′)
n. Abbr. miRNA
Any of various short, single-stranded RNA molecules that regulate gene expression by binding to messenger RNA molecules, usually in untranslated regions.

microRNA

Any of a group of short (generally 21 to 24 nucleotides in length), non-coding RNA molecules which fold upon themselves (“hairpins”) and are usually cleaved from larger hairpin-containing RNA (itself often processed from some portion of mRNA).

MiRNA is conserved through evolution and plays a role in RNA interference, destroying mRNA made by specific genes, suppressing gene expression and controlling translation of target mRNAs, thereby regulating critical aspects of plant and animal development.

microRNA

(mī′krō-ăr′ĕn″ā″) [″ + ″],

miRNA

Oligonucleotides that prevent a variety of messenger RNAs from being transcribed from DNA or translated into proteins. They typically consist of 21 to 25 linked nucleotides.

microRNA

Very short segments of RNA involved in RNA INTERFERENCE and recently shown to be important elements in the development of plant structure. Many genes that code for microRNA have been found in many species including H. sapiens . There is much current speculation into their role in human development.
References in periodicals archive ?
As a leader in the microRNA field, Rosetta Genomics continues to advance and develop microRNA-based technologies that can potentially be applied in a wide range of diagnostics and therapeutics.
He is a recognized world expert in the preclinical and clinical development of oligonucleotide-based therapeutics and led the project that brought the first microRNA inhibitor into human clinical trials.
This study reveals a new function of microRNA, which we show binds to a protein receptor," Dr.
These microRNAs help control production of proteins, including some involved in cell proliferation.
MicroRNAs (miRNAs) are recently discovered, naturally occurring small RNAs that act as master regulators and have the potential to form the basis for a new class of diagnostics and therapeutics.
14 January 2014 - US Regulus Therapeutics (NASDAQ:RGLS), a developer of drugs targeting microRNAs, said yesterday it had set up a new R&D division, Regulus microMarkers, focused on expansion of its novel biomarkers platform for discovery of microRNAs as disease biomarkers.
November 15, 2017 -- Scientists here have partly solved a long-unanswered basic question about stem cells: Why are pluripotent stem cells that have mutations to block the production of microRNAs unable to differentiate?
Several cardiac biomarkers have already been shown to be useful in the evaluation of a variety of diseases (BOSWOOD, 2009) and, similarly, the evaluation of microRNA expression in heart diseases may well provide a noninvasive technique for gathering information to aid diagnosis and prognosis which could lead to the development of new therapeutic protocols.
RosettaGX Reveal, a Thyroid microRNA Classifier for the diagnosis of cancer in thyroid nodules, as well as the full RosettaGX portfolio of cancer testing services are commercially available through the company's Philadelphia, PA- and Lake Forest, CA-based CAP-accredited, CLIA-certified labs.
The aspects of the microRNA market - research, diagnostics, and therapeutics - all hold major importance in various areas of the healthcare and pharmaceutical industries.
Researchers at Otago University discovered that a small number of a large class of molecules called microRNA - found in both the human brain and blood - were exceptionally good at detecting Alzheimer's disease, a debilitating form of dementia.
When researchers gave the microRNA-deficient mice infusions of normal microRNA mixes, the rodents had less severe symptoms.