Michaelis-Menten equation


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Mi·chae·lis-Men·ten e·qua·tion

(mi-kā'lis men'tĕn),
an initial-rate equation for a single-substrate noncooperative enzyme-catalyzed reaction relating the initial velocity to the initial substrate concentration; v = Vmax [S]/(Km + [S]), where v is the initial velocity of the reaction, Vmax is the maximum velocity, [S] is the initial substrate concentration, and Km is the Michaelis constant. Similar equations can be derived for conditions in which the product is present and for multisubstrate enzymes.
[Leonor michaelis, Maud L. Menten]

Michaelis-Menten equation

An equation for evaluating enzyme kinetics in a system: v = VS/Km + S, where v = Initial velocity of reaction; V = Maximum (or limiting) velocity; S = Substrate concentration; and Km =  Michaelis constant.

The MME assumes that rapid equilibrium is reached among the enzyme, its substrate and the enzyme-substrate complex, and that the initial velocity of the reaction is proportional to the concentration of the enzyme-substrate complex.

Menten,

Maud Leonora, Canadian pathologist in U.S., 1879-1960.
Michaelis-Menten constant - Synonym(s): Michaelis constant
Michaelis-Menten equation - see under Michaelis
Michaelis-Menten hypothesis - see under Michaelis
Victor-Michaelis-Menten equation - Synonym(s): Michaelis-Menten equation

Michaelis,

Leonor, German-U.S. chemist and physician, 1875-1949.
Michaelis buffer
Michaelis constant - the true dissociation constant for the enzyme-substrate binary complex in a single-substrate rapid equilibrium enzyme-catalyzed reaction. Synonym(s): Michaelis-Menten constant
Michaelis-Gutmann body - a rounded homogenous body containing calcium and iron found within macrophages in the bladder wall in malacoplakia.
Michaelis-Menten constant - Synonym(s): Michaelis constant
Michaelis-Menten equation - an initial-rate equation for a single-substrate noncooperative enzyme-catalyzed reaction relating the initial velocity to the initial substrate concentration. Synonym(s): Victor-Michaelis-Menten equation
Michaelis-Menten hypothesis - that a complex is formed between an enzyme and its substrate (the O'Sullivan-Tompson hypothesis), which complex then decomposes to yield free enzyme and the reaction products (Brown hypothesis), the latter rate determining the overall rate of substrate-product conversion.
Victor-Michaelis-Menten equation - Synonym(s): Michaelis-Menten equation
References in periodicals archive ?
app] value of produced glucose biosensor was calculated from the slope and intercept values of Michaelis-Menten equation.
0]) can be related to the equilibrium constant and the capacity of the adsorbent by an equation resembling to the Michaelis-Menten equation (Eq.
Combined, the new results could mean models of enzyme kinetics based on the Michaelis-Menten equation are wrong.
Fitting the data on concentration dependency with the Michaelis-Menten equation (Fig.
A linear version of the Michaelis-Menten equation is the Lineweaver-Burke plot (Figure 12-1).
oleracea genotypes in their responses to P supply can be accounted for entirely by one or both of the fitted parameters of the Michaelis-Menten equation.
Taking into consideration that the kinetics of denitrification is based on enzyme activity, the rate equation describing the process by activated sludge can be based on the Michaelis-Menten equation for the two substrate process.
We estimated the maximal species richness at each elevation by fitting the Michaelis-Menten equation (Raaijmakers 1987) and by computing Chao's (1984) estimator (reviewed in Colwell and Coddington 1994).
We used a modified form of the Michaelis-Menten equation that also estimates body mass at birth (M.
This resulted in the Michaelis-Menten equation, a basic biochemical concept that brought them international recognition.