# Michaelis-Menten equation

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## Mi·chae·lis-Men·ten e·qua·tion

(mi-kā'lis men'tĕn),an initial-rate equation for a single-substrate noncooperative enzyme-catalyzed reaction relating the initial velocity to the initial substrate concentration;

*v*=*V*_{max}[S]/(*K*_{m}+ [S]), where*v*is the initial velocity of the reaction,*V*_{max}is the maximum velocity, [S] is the initial substrate concentration, and*K*_{m}is the Michaelis constant. Similar equations can be derived for conditions in which the product is present and for multisubstrate enzymes. Synonym(s): Henri-Michaelis-Menten equation

[Leonor

*michaelis*, Maud L.*Menten*]## Michaelis-Menten equation

An equation for evaluating enzyme kinetics in a system: v = VS/Km + S, where v = Initial velocity of reaction; V = Maximum (or limiting) velocity; S = Substrate concentration; and Km = Michaelis constant.The MME assumes that rapid equilibrium is reached among the enzyme, its substrate and the enzyme-substrate complex, and that the initial velocity of the reaction is proportional to the concentration of the enzyme-substrate complex.

## Menten,

Maud Leonora, Canadian pathologist in U.S., 1879-1960.**Michaelis-Menten constant**- Synonym(s): Michaelis constant

**Michaelis-Menten equation**- see under Michaelis

**Michaelis-Menten hypothesis**- see under Michaelis

**Victor-Michaelis-Menten equation**- Synonym(s): Michaelis-Menten equation

## Michaelis,

Leonor, German-U.S. chemist and physician, 1875-1949.**Michaelis buffer**

**Michaelis constant**- the true dissociation constant for the enzyme-substrate binary complex in a single-substrate rapid equilibrium enzyme-catalyzed reaction. Synonym(s): Michaelis-Menten constant

**Michaelis-Gutmann body**- a rounded homogenous body containing calcium and iron found within macrophages in the bladder wall in malacoplakia.

**Michaelis-Menten constant**- Synonym(s): Michaelis constant

**Michaelis-Menten equation**- an initial-rate equation for a single-substrate noncooperative enzyme-catalyzed reaction relating the initial velocity to the initial substrate concentration. Synonym(s): Victor-Michaelis-Menten equation

**Michaelis-Menten hypothesis**- that a complex is formed between an enzyme and its substrate (the O'Sullivan-Tompson hypothesis), which complex then decomposes to yield free enzyme and the reaction products (Brown hypothesis), the latter rate determining the overall rate of substrate-product conversion.

**Victor-Michaelis-Menten equation**- Synonym(s): Michaelis-Menten equation

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