T-type calcium channel antagonists, mibefradil
and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines.
* LATUDA should not be used concomitantly with strongCYP3A4 inhibitors (eg, ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil
In addition, we measured the [Ca.sup.2+] current in [Na.sup.+]-free solution plus 20 [micro]M TTX, which is sensitive to mibefradil
, a T-type calcium channel blocker.
(fenfluramine), Posicor (mibefradil
), and Duract (bromfenac) in 1997,
Exclusion criteria were the following: (1) coronary heart disease; (2) allergy to simvastatin; (3) active hepatitis and/or severe renal impairment (serum creatinine > 200 [micro]mol/L); (4) pregnancy or lactation; (5) taking medication(s) that may increase the effective concentration of simvastatin (e.g., a tetralol-derived calcium-channel blocker such as mibefradil
); and (6) hyperlipidemia.
Several medicines were withdrawn from the market due to their interaction with other substances (mainly related to the CYPs) for example: Seldane[R] (Terfenadine, Aventis Pharmaceuticals, USA), Posicor[R] (Mibefradil
, Roche, Switzerland), Propulsid[R] (Cisapride, Janssen-Ortho, Canada), Lotronex[R] (Alosetron, Prometheus Laboratories Inc., USA), Baycol[R] (Cerivastatin, Bayer A.G., Germany) and Serzone[R] (Nefazodone, Bristol-Myers Squibb, USA) (25).
Sodium hydrosulfide hydrate (NaHS), EGTA, thapsigargin (TG), nifedipine, nimodipine, and mibefradil
were obtained from Sigma-Aldrich.
* Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil
, etc.) [see Drug Interactions (7.1)].
Anti-adhering and anti-migratory compounds ilomastat (a matrix metalloproteinase inhibitor), naphtyl urea suramin,  salmosin (a disintegrin),  mibefradil
(Ca- channel inhibitor),  RGD peptide, EDTA,  and coating an acrylic IOL surface with MPC polymer; 
Nam et al., "Facilitation of [Ca.sup.2+]-activated [K.sup.+] channels (IKCa1) by mibefradil
in B lymphocytes," Pflugers Archiv European Journal of Physiology, vol.
All drugs were prepared as stock solutions: capsaicin (10 mM) in DMSO, [Ni.sup.2+] (100 mM), and mibefradil
(5 mM) in [H.sub.2]O.
However, selective blockade of [Ca.sub.v]3 (T-type) calcium channels located predominantly in ICCs with mibefradil
(3 [micro]M) significantly (P < 0.05) depressed the outflow of adenine nucleosides from both control and TNBS-treated preparations (Figure 4).