KCNE3

(redirected from MiRP2)

KCNE3

A gene on chromosome 11q13.4 that encodes a beta subunit of the voltage-gated, isk-related potassium channel subfamily. This type-I membrane protein assembles with a potassium channel alpha-subunit to modulate gating kinetics and stabilise the multimeric complex. It is primarily expressed in the kidneys.

Molecular pathology
KCNE3 mutations are associated with hypokalemic periodic paralysis.
References in periodicals archive ?
Within the three exons of KCNE3, it is known that KCNE3-exon-3, where we found 492 A/C SNPs, participates in encoding protein MIRP2. Therefore, 492 A/C SNPs are also cSNPs.
Based on the present studies and the results of our previous experiments, we proposed the "KCNE1-SMD, KCNE3-FMD"assumption that KCNE1 encodes protein Mink, and gene mutations of its functional exon 2 affect the beta subunit synthesis of K (+) channels, thus involving the onset of the SMD process, and that KCNE3 encodes protein MIRP2, and gene mutations of its functional exon 3 affect the functional K (+) channels on the lymph sac, thus involving the onset of the FMD process.
Coeficientes Estandarizados de las variables Canonicas de la Prediccion 4 Variable Coeficiente ATD1 0.888934791 NDVID1 0.823421597 NDIVIA1 -0.628877461 ATA2 -0.512016237 NDVIMX 0.332730114 MIRP2 -0.328334123 ATP2 -0.293035269 MIRP1 -0.223063365 Eigenval 0.429521561 Tabla 10.