KCNE3

(redirected from MiRP2)

KCNE3

A gene on chromosome 11q13.4 that encodes a beta subunit of the voltage-gated, isk-related potassium channel subfamily. This type-I membrane protein assembles with a potassium channel alpha-subunit to modulate gating kinetics and stabilise the multimeric complex. It is primarily expressed in the kidneys.

Molecular pathology
KCNE3 mutations are associated with hypokalemic periodic paralysis.
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References in periodicals archive ?
Within the three exons of KCNE3, it is known that KCNE3-exon-3, where we found 492 A/C SNPs, participates in encoding protein MIRP2. Therefore, 492 A/C SNPs are also cSNPs.
Based on the present studies and the results of our previous experiments, we proposed the "KCNE1-SMD, KCNE3-FMD"assumption that KCNE1 encodes protein Mink, and gene mutations of its functional exon 2 affect the beta subunit synthesis of K (+) channels, thus involving the onset of the SMD process, and that KCNE3 encodes protein MIRP2, and gene mutations of its functional exon 3 affect the functional K (+) channels on the lymph sac, thus involving the onset of the FMD process.