[alpha]7, alpha-7 nicotinic receptor; CB1, cannabinoid receptor type 1; CN, Calcineurin; DAO, D-amino acid oxidase; DISC1, Disrupted-In-Schizophrenia 1; DTNBP1, Dysbindin; ErbB4, Erythroblastic leukemia viral oncogene homolog 4; FMRP, fragile X mental retardation protein; G72 (also known as D-amino acid oxidase activator); Kal-7, Kalirin-7; mGluR
, metabotropic glutamate receptor; NL, Neuroligin; NR1, NMDA-R, NR1 Subunit; NR2, NMDA-R, NR2 Subunit, NRG1, Neuregulin 1; PICK1, protein kinase C alpha binding protein.
Presynaptic m1 muscarinic receptors are necessary for mGluR
long term depression in the hippocampus.
Glutamate acts via ionotropic glutamate receptors (iGluR) and metabotropic glutamate receptors (mGluR
), both of which have been implicated in AD (52).
NIH-funded scientists working with mice having the same genetic mutation found in Fragile X syndrome learned that the mice have increased activity in the metabotropic glutamate receptor (mGluR
), which sits atop brain cells.
Metabotropic glutamate receptor 7 (mGluR7) is a member of the mGluR
Aevi Genomic Medicine announced that it will increase the sample size for Part A of its Phase 2 ASCEND clinical trial, which is enrolling a mGluR
mutation positive genetic subset of pediatric and adolescent patients with Attention Deficit Hyperactivity Disorder, or ADHD, to confirm response to AEVI-001 in these patients.
Associative training for early odor preference learning down-regulates synapse-specific NMDA receptors via mGluR
and calcineurin activation," Cerebral Cortex, vol.
The slow and fast modes target NMDA and mGluR
receptors, respectively .
The main mechanism of action of DMT appears to partial agonism on serotonergic 2A ([5-HT.sub.2A]) receptors expressed on layer V cortical neurons, a process that also seems to involve metabotropic glutamate receptors (mGluR
That is, the larger [mathematical expression not reproducible], the larger density of distribution of mGluR
on the membrane.
Interventions that were found to have some beneficial effect in preclinical studies include non-NMDA and NMDA receptor antagonists, mGluR1 and mGluR5 antagonists, agonists for group II mGluR2/3 and group Ill mGluR
, including mGluR8, antagonists for CGRP1 and CRF1 receptors, neuropeptide S activating NPS receptors, and inhibitors of ERK and PKA (reviewed in ).
Turzynska et al., "The effects of group III mGluR
ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration," Brain Research, vol.