Effects of Zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus Basalis of
Meynert in rat.
[1] A deficiency of intact cholinergic neurons, particularly those extending from subcortical areas like the nucleus of
Meynert has been observed with progressive dementia.
Murray et al., "Daytime sleepiness in dementia with Lewy bodies is associated with neuronal depletion of the nucleus basalis of
Meynert," Parkinsonism & Related Disorders, vol.
Perry et al., "Pathological changes in the nucleus of
Meynert in Alzheimer's and Parkinson's diseases," Journal of the Neurological Sciences, vol.
In the new studies, scientists used the technique of placing hair-thin electrodes into the brain to deliver electricity and increase the activity of the nucleus basalis of
Meynert, a small area in the forebrain that is inexplicably degenerated in both Parkinson's and Alzheimer's.
Swanson, "Midbrain, diencephalic and cortical relationships of the basal nucleus of
Meynert and associated structures in primates," Journal of Comparative Neurology, vol.
These include the cholinergic system (nucleus basasils of
Meynert), the serotonergic system, and the noradrenergic system (Jellinger, 1999).
To date, only 1 human study of DBS with bilateral STN and nucleus basalis of
Meynert (NBM) stimulation in PD dementia (PDD) has evaluated
In line with the aforementioned reports, jujube was reported to possess repairing effects on memory and learning impairment induced by bilateral electric lesion of the nucleus basalis of
Meynert in rats [25].
In this paper, which was published only in 1950, Freud adopted 'brain mythology' supported by Wilhelm Griesinger (1817-1868) and Theodor
Meynert (1833-1892) who was one of Freud's teachers.