methyltransferase

(redirected from Methyltransferases)
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methyltransferase

 [meth″il-trans´fer-ās]
any enzyme that catalyzes transmethylation.

meth·yl·trans·fer·ase

(meth'il-trans'fer-ās),
Any enzyme transferring methyl groups from one compound to another.

meth·yl·trans·fer·ase

(meth'il-trans'fĕr-ās)
Any enzyme transferring methyl groups from one compound to another.
Synonym(s): transmethylase.
References in periodicals archive ?
The new study looked at an epigenetic therapy that inhibits the enzyme G9a, a type of histone methyltransferase.
Suppressor of enhancer of zeste homolog 2 (EZH2) is a methyltransferase responsible for laying down the H3K27me3 mark on the chromatin [15, 16].
Investigational PARP inhibitor talazoparib and DNA methyltransferase (DNMT) inhibitor decitabine will be used in conjunction.
Methylated C1 substrates are channeled into the methylotrophic pathway of methanogenesis by substrate-specific methyltransferases [21].
The histone methyltransferases (SET1, G9a, SUV39H1, and SUV39H2) and the histone demethylases (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) gene expression was detected by real-time quantitative PCR.
The full length and all deletion constructs for methyltransferases and demethylases were cloned into pKH3-HA vector.
These carcinogens also increase expression of the eukaryotic DNA methyltransferases DNMT1 and DNMT3B.
Mode of transposition and expression of 16S rRNA methyltransferases gene rmtC accompanied by ISEcp1.
CpG sites are regions of DNA wherein a cytosine nucleotide becomes methylated through DNA methyltransferase enzymes which have the net effect of suppressing gene transcription.
Raymond Trievel, Associate Professor of Biological Chemistry at the University of Michigan added, "The development of the SAM-Screener[TM] provides new chemical tools for studying substrate recognition by methyltransferases and offers a flexible platform for identifying SAM-competitive inhibitors, particularly for methyltransferases that are targets for the design of novel therapeutics to treat cancer and other diseases."
Background: Protein arginine methyltransferases 1 (PRMT1) is over-expressed in a variety of cancers, including lung cancer, and is correlated with a poor prognosis of tumor development.
Mammalian methyltransferases and methyl-CpG-binding domains: proteins involved in DNA methylation.