methylglyoxal


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meth·yl·gly·ox·al

(meth'il-glī-ok'săl),
Pyruvaldehyde; the aldehyde of pyruvic acid; an intermediate of carbohydrate metabolism in certain organisms.
Synonym(s): pyruvic aldehyde

methylglyoxal

(mĕth″ĭl-glī-ŏk′sĭl, -awl)
An aldehyde formed from the metabolic degradation of glucose. Methylglyoxal can bind to proteins and DNA, causing metabolic damage to tissues (e.g., in diabetes mellitus), mutations, or cell death.
References in periodicals archive ?
True Honey Co measures the antibacterial quality of honey by MGO reliable grading system (Methylglyoxal) is a compound found in the pollen of the Manuka tree's -(Leptospermum scoparium) flowers which is responsible for the antibacterial /antimicrobial properties of Manuka Honey.
The investigation revealed that synthetic chemicals, methylglyoxal (MGO) and dihydroxyacetone (DHA) were being added to the companys honey.
In addition, Ni can activate an isoform of glyoxalase I that catalyze an important step in the degradation of methylglyoxal (MG), a compound naturally produced by cellular metabolism that may be lethal to cell functions.
MGO (methylglyoxal), is the magic ingredient that gives manuka honey its health-boosting effects.
Further evidence of carnosine's anti-crosslinking ability comes from how it neutralizes methylglyoxal, (3,19,20) a byproduct of excessive blood sugar that has been associated with many of the complications of type II diabetes, including damage to eyes, brain, kidneys, and other organs.
Advanced glycation end products (AGEs) are formed by non-enzymatic glycation of proteins or lipids by high serum glucose, methylglyoxal, and 3-deoxy glucosone.
Lower doses of resveratrol pro-tected mouse oocytes from methylglyoxal that induced oxidative damage and inhibited oocytes in the GV stage (23).
Researchers found levels of the toxic chemicals formaldehyde, acrolein and methylglyoxal rose after vaping.
The model was applied to test the cytotoxicity of different neurotoxic agents, such as methyl mercury, iron oxide nanoparticles and methylglyoxal. All tested compounds affected mitochondrial activity and cell morphology in both mono-culture and co-culture conditions.