methylation

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methylation

 [meth″ĭ-la´shun]
the addition of methyl groups.

meth·yl·a·tion

(meth-i-lā'shŭn),
Addition of methyl groups; in histochemistry, used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid, the net effect being to reduce tissue basophilia and abolish metachromasia.

methylation

Chemistry
The addition of a methyl group to a molecule.
 
Molecular biology
The addition of a methyl group to a cytosine residue on double-stranded DNA, a process which plays a major role in regulating gene expression and preventing restriction endonucleases from cutting DNA at their recognition sites.
 
Methylated genes are inactive; the pattern of methylation or imprinting is critical in gene expression, and may be passed from one generation to the next. Genes may be demethylated or methylated de novo according to the cell’s function, or during normal development. Phosphorylation is another form of semi-permanent gene control.

meth·yl·a·tion

(meth'i-lā'shŭn)
Addition of methyl groups; in histochemistry, used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid; the net effect being to reduce tissue basophilia and abolish metachromasia.

methylation

the addition of a methyl group (-CH3) to an AMINO ACID in a PROTEIN, as in, for example, POST-TRANSLATIONAL MODIFICATION, or to a NUCLEOTIDE in a NUCLEIC ACID; see MODIFICATION AND RESTRICTION SYSTEM. See also METHYL TRANSFERASE.

meth·yl·a·tion

(meth'i-lā'shŭn)
Addition of methyl groups; in histochemistry, used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid.
References in periodicals archive ?
In this study, we searched for evidence that additional genetic variants (other than the known AS3MT variants) influence arsenic methylation capacity, measured as the relative concentration of DMA in urine, using various approaches to evaluate polygenic susceptibility.
In this study, we have assessed, for the first time, the overall contribution of genetic variation to arsenic methylation capacity, as measured by DMA%, using SNP-based heritability methods.
In this prospective study, we found an increased risk of fatal and nonfatal CVD, especially heart disease, associated with higher well-water arsenic concentration and lower methylation capacity, indicated by higher urinary MMA% or lower DMA%.
Previous studies have reported evidence of adverse effects of incomplete arsenic methylation capacity on cancer risk.
To better understand the difference in methylation capacity between males and females, we repeated the multiple regression analyses stratified by sex (Table 4).
shRNA silencing of AS3MT expression minimizes arsenic methylation capacity of HepG2 cells.
Abnormal methylation capacity in human liver cirrhosis.
Measures of arsenic exposure, biomarkers of exposure and methylation capacity, and GST genotypes.
The liver is considered the major organ in [As.sup.V] reduction and [As.sup.III] methylation, but also other organs, especially the kidneys, have been shown to exert methylation capacity (Abernathy et al.
1998), differences in the methylation capacity could be of importance.
If genetic factors contribute to arsenic methylation capacity, family studies should demonstrate that siblings have a higher correlation of methylation activity than their parents.
Epidemiological Studies on Inorganic Arsenic Methylation Capacity and Inorganic Arsenic Induced Health Effects Among Residents in the Blackfoot Disease Endemic Area and Lanyang Basin in Taiwan [PhD Thesis].