metformin

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Related to Metformin hcl: Metformin hydrochloride

metformin

 [met-for´min]
a hypoglycemic agent that potentiates the action of insulin; used in treatment of type 2 diabetes mellitus.

metformin

(mĕt-fôr′mĭn)
n.
An oral hypoglycemic drug, C4H11N5, usually used in its hydrochloride form, that decreases glucose production by the liver and increases peripheral glucose uptake, used to treat type 2 diabetes.

metformin

A biguanide antihyperglycaemic and antidiabetic used for type-2 diabetes, alone or with sulfonurea. Metformin sensitises cells to insulin, decreases serum glucose and insulin, decreases insulin resistance, increases glucose utilisation, decreases triglycerides, and reduces weight; in some patients, it suppresses appetite.

Adverse effects
GI tract complaints—e.g., diarrhoea, nausea, vomiting, bloating—occur in 30%.
 
Contraindications
Metabolic acidosis, liver disease; metformin has an equal and additive effect with troglitazone, which acts by increased peripheral glucose disposal.

metformin

Glucophage® Diabetology A biguanide antihyperglycemic and antidiabetic used for type 2 DM, alone or with sulfonurea; metformin sensitizes cells to insulin, ↓ serum glucose and insulin, ↓ insulin resistance, ↑ glucose utilization, ↓ TGs, ↓ weight; in some Pts, it suppresses appetite. See Diabetes mellitus. Cf Troglitazone.

metformin

A biguanide oral HYPOGLYCAEMIC drug used in the treatment of MATURITY ONSET DIABETES. The drug may be dangerous to those with liver or kidney disease or a high alcohol intake. The drug is on the WHO official list. A brand name is Glucophage.

Patient discussion about metformin

Q. does anyone have experience switching from metformin to janumet?

A. ?
Janumet is metformin... it's a generic name for it. metformin is a substance name and there's all kind of drug companies that manufacture it (all in different names and little formula differences).

Q. I'm a diabetic and have been on metformin for aprox. 4 yrs. The Dr. upped my dose and my sugar levels went way up. I stopped taking it and for the last two days sugar levels have stayed between 115 and 135. Whereas, with the higher dose of metformin. It reached 269. Diet is the same. What is going on. And do I trust my Dr. evaluation.

A. I doubt the cause of the sugar rise has any relation to the Metformin increased dosage. It could be your body has stopped reacting to Metformin- that happens to almsot all patients with diabetes after a while, and a combination treatment with another drug or a change in drugs is performed. You should remain on the new dosage for another week or two, and keep track of your sugar level meanwhile, and if things don't improve then you should see your doctor again so that he/she will make a new evaluation.

More discussions about metformin
References in periodicals archive ?
Blood glucose levels that have been given a suspension of metformin HCl decreased from 135 mg/dL to 85 mg/dL.
Metformin HCl was geometrically mixed with release retarding polymers followed by the addition of an effervescent agent.
Forced degradation studies were performed to develop a stability indicating HPLC method for the quantative determination and purity evaluation of metformin HCl bulk drug.
Table 1: System suitability results for Six Injections Injections Area Retention Time (min) 1 1811757 8.317 2 1815088 8.325 3 1818163 8.333 4 1820428 8.333 5 1817515 8.333 Average 1816590 8.3282 SD [+ or -] 3304.319 [+ or -] 0.0072 RSD 0.086% 0.18% Injections Tailing Theoretical Factor Plates 1 1.22 11385 2 1.22 11357 3 1.21 11379 4 1.25 11414 5 1.25 11434 Average 1.23 11393.8 SD [+ or -] 0.018708 [+ or -] 30.310 RSD 1.52% 0.27 % Table 2 : Results of Method Precision Data of Six Different Preparations Preparations Assay 1 99.17 % 2 99.11 % 3 99.20 % 4 99.13 % 5 99.41 % Average 99.20 % SD [+ or -] 0.1976 RSD 0.19 % Table 3: Results of Linearity of The Metformin HCL at Different Levels in The Range 50 % to 150 % of Assay Concentration.
The mix of alogliptin with metformin HCl, KAZANO, is an anti-diabetes medication formulated in a single tablet in addition to single tablet regime OSENI that integrates alogliptin with the thiazolidinedione (TZD) pioglitazone.
29 November 2011 - AstraZeneca (LON:AZN) and Bristol-Myers Squibb Company (NYSE:BMY) said today the European Commission (EC) had granted EU-wide marketing authorisation for the use of KOMBOGLYZE (saxagliptin and metformin HCl immediate-release fixed dose combination) in adult patients with Type 2 diabetes.
Global biopharmaceutical company Bristol-Myers Squibb Company (NYSE:BMY) and AstraZeneca (NYSE:AZN), a biopharmaceutical company, announced on Friday that KOMBIGLYZE XR (saxagliptin and metformin HCl extended-release) is now available by prescription in pharmacies across the US.
Biopharmaceutical company Santarus Inc (NASDAQ:SNTS) and pharmaceutical company Depomed Inc (NASDAQ:DEPO) jointly reported on Wednesday the resumption of the supply of GLUMETZA 500 mg (metformin HCl extended release tablets) to wholesalers and retailers.
Food and Drug Administration (FDA) has issued a Complete Response Letter regarding Mercks Supplemental New Drug Applications for JANUVIA (sitagliptin), JANUMET (sitagliptin and metformin HCl) and JANUMET XR (sitagliptin and metformin HCl extended-release).
says it entered into a settlement with Takeda for Actoplus Met, 15 mg/500 mg and 15 mg/850 mg, known generically as pioglitazone hydrochloride (HCl) and metformin HCl tablets, and Actos, 15 mg, 30 mg and 45 mg, known generically as pioglitazone HCl tablets.
Tenders are invited for Vildagliptin 50Mg With Metformin Hcl 500Mg Tab In Strip
unit have begun marketing PrandiMet (repaglinide and metformin HCl) tablets.