S100A4

(redirected from Metastasin)

S100A4

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A4-encoded protein is thought to play a role in motility, invasion and tubulin polymerisation.
 
Molecular pathology
S100A4 rearrangements have been implicated in tumour metastasis.
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References in periodicals archive ?
Different forms of cancer exhibit dramatic changes in the expression of S100 proteins such as S100B, S100A2, S100A4, S100A6, and S100P.[32] For example, elevated levels of S100A4 (metastasin) are associated with poor survival rates in human breast cancer patients and have been found to induce metastasis in mouse models.
S100A4, which is a multifunctional [Ca.sup.2+] signaling protein found in the cytoplasm and extracellular space, is also called metastasin (Mts1), pEL-98, 18A2, 42A, p9Ka, CAPL, calvasculin, and fibroblast-specific protein (FSP1) [11,12,16].