Finally, it is suggested that future studies be directed to the regulation of the genetic expression of metalloproteins
and their relation in the adaptation of plants to low Zn, in order to pave the way for the development of new strategies to improve the tolerance of plants to Zn deficiency.
A study by Rullsekr and Vondrasek on the coordination geometries of selected metal ions in metalloproteins
with data from the Protein Data Bank suggests that [Ni.sup.2+], [Cu.sup.2+], and [Zn.sup.2+] tend to bind in tetrahedral coordination modes although there are other geometries such as octahedral and square planar .
Handbook of Metalloproteins
. John Wiley and Sons, Ltd., New York, USA
C23D is from the class of metalloproteins
and generally uses iron as a co factor but active site which uses Mn+2 as a cofactor is also known (Vaillancourt et al., 2006).
Further assays were performed with the metalloproteins
and cathepsin extracts from the lean and steatotic liver.
Some of the enzymes are metalloproteins
, of which curcumin may affect directly by metal chelation.
: Theory, Calculations, and Experiments
In the case of Zn exposure, the literature indicates the involvement of oxidative stress generation induced by glutathione (GSH) depletion, extrapolation of metalloproteins
binding capacity, such as metallothionein, and the interference with the redox state of macromolecules (KIM et al., 2003; SLIWINSKI et al., 2009).
Myosinases belong to a large family of astacin-like metalloproteins
that have numerous functions and are widely distributed in nature, although in many cases their role is unknown.
* Ability to invade and metastasis: Biologic hallmark of malignant neoplasm for invasion and metastasis are integrins & matrix metalloproteins
In case of N and C based functionalized macrocyclic ligands, the mode of metal incorporation is very much similar to that of metalloproteins
in which the requisite metal is bound in a macrocyclic cavity or cleft produced by the conformational arrangement of the protein .
Poole II et al., "A computational framework for proteome-wide pursuit and prediction of metalloproteins
using ICP-MS and MS/MS data," BMC Bioinformatics, vol.