Fox, "Interaction of the cysteine-rich domain of snake venom metalloproteinases
with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation," FEBS Journal, vol.
One group of enzymes that is important in mediating IRI injury is the family of matrix metalloproteinases
in biology and pathology of the nervous system.
(11,12) These products are rich in polyphenols and have been reported to be inhibitors of the activity of different metalloproteinases
. (11,13) It has been suggested that the use of synthetic inhibitors of MMPs could be used to control the loss of the dentin matrix.
Their proteolytic activity is regulated at transcriptional and posttranslational levels but also at the tissue level by endogenous inhibitors, known as tissue inhibitors of metalloproteinases
(TIMPs 1-4) .
Matrix components are regulated by matrix metalloproteinases
(MMPs) such as MMP2, MMP9 (9).
Current mechanistic insights into the roles of matrix metalloproteinases
in tumour invasion and metastasis.
[12.] Chaussain-Miller C1, Fioretti F, Goldberg M, Menashi S (2006) The role of matrix metalloproteinases
(MMPs) in human caries, Journal of Dental Research 85:22-32.
are vital in the invasive and metastatic properties of cancer cells, and their expression (particularly MMP-2 and MMP-9) is promoted in a range of carcinomas (Deryugina and Quigley, 2006).
Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases
. Oncotarget 2017; 8: 14283-93.
Ovarian tissue remodeling: role of matrix metalloproteinases
and their inhibitors.
Expression of matrix metalloproteinases
and tissue inhibitors of metalloproteinases
in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression.