methacholine

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Related to Metacholine: Methacholine challenge test

methacholine

 [meth″ah-ko´lēn]
a cholinergic agonist, having a longer duration of action than acetylcholine and predominantly muscarinic effects; it has vasodilator and cardiac vagomimetic effects but has largely been replaced by other drugs. It is also used in bronchial challenge tests.
References in periodicals archive ?
Metacholine challenge tests were performed in those 5 subjects.
* Asthma--up to 50% of patients with CRS have asthma or bronchial hyperreactivity after metacholine challenge.
The influx of eosinophils, macrophages, and lymphocytes into the airways was also markedly suppressed; however, these mice remained hyperresponsive to metacholine. Together, these data provide experimental evidence that prenatal exposure to a microbial component such as LPS can modify the immune response to allergen exposure later in life.