"Altar has been collaborating with Braskem over the last two years as a facilitator of its metabolic engineering projects and we have nothing but high expectations for the multi-project partnership with a global leader in sustainable chemicals," said Trancart.
Josh Michener, of ORNLs Biosciences Division, was selected for his proposal, Systems Metabolic Engineering of Novosphingobium aromaticivorans for Lignin Valorization, by the Office of Biological and Environmental Research.
The development means that researchers are now able to identify the genes that produce a wealth of valuable compounds, and then turn them into drug candidates using metabolic engineering techniques in the lab.
Microbial fermentation continues to be the most effective production method for coenzyme Q10, with the advent of novel tools in the field of synthetic biology that offer new possibilities beyond traditional forms of metabolic engineering. Chemical synthesis for production of CoQ10 is slightly losing traction on account of numerous costs involved such as in high energy catalysis reactions.
However, certain cancer cells can activate alternative ways to generate energy and thereby escape the drug's action.This is where a new research approach called "rational metabolic engineering" comes in.
The company plans to invest around EUR 3.6m in a new laboratory facility and will be moving the employees of the metabolic engineering division to the new site as well as accommodating 30-40 research scientists.
Alternatively, one can create independent analysis tools that simply use GEMs to identify product synthesis pathways [53-56], optimize bioprocessing efficiency [57, 58], predict metabolic engineering targets [58, 59], and elucidate more complex phenomena such as symbiosis in microbial communities [24, 60-63].