TPN

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Related to Metabolic defects: Birth defects, Inborn errors of metabolism

TPN

 

TPN

Abbreviation for total parenteral nutrition.

TPN

abbr.
total parenteral nutrition

TPN

Total parenteral nutrition IV hyperalimentation Critical care A modality that attempts to provide all the body's need for nutrition without using the GI tract Indications
1. Correction of nutritional depletion in the face of inadequate oral intake and/or intestinal absorption, as in Crohn's disease, malignancy, pseudo-obstruction, radiation enteritis, short bowel syndrome, sprue and.
2. Conditions requiring bowel rest and nutritional restitution–eg, nonspecific colitides and associated growth retardation, enterocutaneous fistulas and pancreatitis TPN is used for children with diaphragmatic hernia, malrotation, esophageal atresia, tracheoesophageal fistula, gastroschisis, volvulus, meconium ileus and omphalocele; severely malnourished See Cancer cachexia. Cf Enteral nutrition.
Complications of TPN
Hepatic dysfunction Cholestasis, cholelithiasis, hepatic dysfunction, jaundice, hepatomegaly, micronodular cirrhosis, lipofuscinosis and steatosis–most common in premature infants
Related to indwelling IV line Misplacement of line, infections, eg Candida spp, aspergillosis
Metabolic defects Hyperglycemia–osmotic diuresis, hyperosmolarity, post-infusion hypoglycemia, hyperosmolar coma, ketoacidosis and other metabolic derangements, excess or deficiency of electrolytes, including Na+, K+, Cl, eg hyperchloremic acidosis and mineral imbalances, affecting Mg2+, PO4, and Ca2+ with hypercalcemia and accompanying pancreatitis, hypercalciuria and metabolic bone disease
Nutritional imbalances Generalized ↓ in essential fatty acids, trace minerals–copper, chromium, molybdenum, tin, zinc, and vitamins and ↑ TGs, cholesterol
.

TPN

Abbreviation for three-in-one total parenteral nutrition; total parenteral nutrition; triphosphopyridine nucleotide.

Total parenteral nutrition (TPN)

A solution containing all the required nutrients including protein, fat, calories, vitamins, and minerals, is injected over the course of several hours, into a vein. TPN provides a complete and balanced source of nutrients for patients who cannot consume a normal diet.

TPN

Abbreviation for total parenteral nutrition.

Patient discussion about TPN

Q. why is it that some women lack parental nutrition?

A. Do you mean breastfeeding? Some women have problem with their nipples, in rare cases the breast tissue isn't developed enough. Sometimes breast surgeries damage the milk ducts. Psychological factors also play a role.

More discussions about TPN
References in periodicals archive ?
Four chief factors are cholestasis, infection, anatomic abnormity of bile duct, and bile metabolic defect. Lacking highly effective procedure for the management though, more strategies for the prevention and treatment will be formulated with the further study of the etiology and pathogenesis of intrahepatic stones.
Secondary metabolic defects in spinal muscular atrophy type II.
Apart from insulin resistance, hyperglucagonemia, increased hepatic sensitivity to glucagon, lipotoxicity, and glucotoxicity all enhance hepatic gluconeogenesis.1 In spite of detailed characterization of the hepatic contribution to diabetes, few molecules target this metabolic defect. Metformin, and the glucagon- like peptide 1 (GLP1) agonists liraglutide and exenatide suppress hepatic gluconeogenesis.
Alloisoleucine plasma concentrations were also evaluated in several metabolic defects. In patients with diabetes mellitus exhibiting significantly increased mean leucine (53%), valine (36%), and isoleucine (35%) plasma concentrations (P <<0.001 vs adult controls), alloisoleucine concentrations were comparable to control concentrations (see Table 1).
5 Reagents for Laboratory of Metabolic Defects along with the lease reader PLN 422
Dr James Otvos, LipoScience's chief scientific officer, commented that the results suggest that a much more refined assessment of diabetes risk beyond that provided by glucose measurements can be made by taking account of the underlying metabolic defects that lead to Type 2 diabetes.
After gastric bypass, I'm becoming more and more convinced that metabolic defects can dramatically improve.
"These findings are very exciting, and for the first time tentatively link type-2 diabetic metabolic defects to increasing dementia mediated by E--amyloid production," he added.
"The knowledge of this diagnosis, along with other fatty-acid metabolic defects, may be very important to the families of affected infants because of the genetic nature of these abnormalities", Bennett said.
This proposal investigates key questions in understanding differential tissue involvement in metabolic defects, and will provide new directions for utilization of tissue-specific adaptations in finding interventions for mitochondrial diseases.
Besides the documented cases involving true inborn errors of glutathione synthesis resulting in 5-oxoprolinuria, some cases of apparently induced states of 5-oxoprolinuria without any evidence of inherited metabolic defects in the [gamma]-glutamyl cycle have also been reported.
Recent findings in rodents strongly indicate that administration of leptin (a slow-acting, glycemia-lowering hormone) reverses the lethal consequences and many of the metabolic defects caused by insulin deficiency.