metabolic bone disease


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Related to metabolic bone disease: osteoporosis

metabolic bone disease

Any defect in bone absorption or deposition that alters the PTH/calcium-phosphate/vitamin D axis, often with increased bone fragility.
 
Aetiology
• Acquired—Fibrous dysplasia, Langerhans cell histiocytosis/histiocytosis X, acromegaly, corticosteroid therapy, heparin, hyperparathyroidism, hyperthyroidism, rickets, immobilisation syndrome, bone metastases, metabolic disease.
• Congenital—Ehlers-Danlos syndrome, homocystinuria, hypophosphatasia, Marfan syndrome, osteogenesis imperfecta, osteoporosis, Paget’s disease of bone (osteitis deformans).
 
Diagnostic workup
Measure Ca2+, PO4–, PTH, other hormones, bone biopsy, tetracycline test.

metabolic bone disease

Any defect in bone absorption or deposition that alters the PTH/calcium-phosphate/vitamin D axis, often with ↑ bone fragility Etiology Fibrous dysplasia, Langerhans' cell histiocytosis/histiocytosis X, acromegaly, corticosteroid therapy, heparin, hyperparathyroidism, hyperthyroidism, rickets, immobilization syndrome, bone metastases, metabolic disease, congenital–Ehlers-Danlos syndrome, homocystinuria, hypophosphatasia, Marfan syndrome, osteogenesis imperfecta, osteoporosis, Paget's disease of bone–osteitis deformans Diagnostic workup Measure Ca2+, PO4–, PTH, other hormones, bone biopsy, tetracycline test
References in periodicals archive ?
Severe metabolic bone disease as a long-term complication of obesity surgery.
Metabolic bone disease is a significant problem in patients with Crohn's disease (1,5,7).
Collagen crosslinks in metabolic bone disease. Acta Orthop Scand.
Metabolic bone disease (MBD) directly affects musculoskeletal health, 4 and may impair the ability of the body to withstand the physiologic stresses of pregnancy and labour.
Metabolic bone disease is a common yet preventable condition in waterfowl living in public parks.
Speakers highlighted overview of Thalessemia, Management of Thalessemia with emphasis on Hb-F Augmentation and BMT, Treatment of Complications/Iron Chelation Therapy, Metabolic Bone Disease in Thalessemia, Bone Marrow Transplant - Experience in AFBMT, Splenectomy in Patients of Thalessemia and Prevention of Thalessemia.
Primary hyperparathyroidism is no longer typically characterized by the classic florid manifestations involving metabolic bone disease, GI disturbances, and nephrolithiasis.
Despite also being diagnosed with metabolic bone disease and having to use a wheelchair, Summer is determined to take part in the 2k fun run - which takes place before the main 10k race on September 11 - after she was inspired by her aunt, Nikki Carter, who ran the Paris Marathon in aid of Kidney Wales.
The 28-year-old has been participating in a hypoparathyroidism research study conducted by the Metabolic Bone Disease Unit at Columbia University in New York since 2006.
The prevalence and incidence of metabolic bone disease are rising as the population ages (1).
Six patients had metabolic bone disease (four osteoporosis, one Paget's, one scleroderma), and three patients had rheumatoid arthritis.
Metabolic bone disease remains a significant and common complication of CD.