metabolic bone disease


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Related to metabolic bone disease: osteoporosis

metabolic bone disease

Any defect in bone absorption or deposition that alters the PTH/calcium-phosphate/vitamin D axis, often with increased bone fragility.
 
Aetiology
• Acquired—Fibrous dysplasia, Langerhans cell histiocytosis/histiocytosis X, acromegaly, corticosteroid therapy, heparin, hyperparathyroidism, hyperthyroidism, rickets, immobilisation syndrome, bone metastases, metabolic disease.
• Congenital—Ehlers-Danlos syndrome, homocystinuria, hypophosphatasia, Marfan syndrome, osteogenesis imperfecta, osteoporosis, Paget’s disease of bone (osteitis deformans).
 
Diagnostic workup
Measure Ca2+, PO4–, PTH, other hormones, bone biopsy, tetracycline test.

metabolic bone disease

Any defect in bone absorption or deposition that alters the PTH/calcium-phosphate/vitamin D axis, often with ↑ bone fragility Etiology Fibrous dysplasia, Langerhans' cell histiocytosis/histiocytosis X, acromegaly, corticosteroid therapy, heparin, hyperparathyroidism, hyperthyroidism, rickets, immobilization syndrome, bone metastases, metabolic disease, congenital–Ehlers-Danlos syndrome, homocystinuria, hypophosphatasia, Marfan syndrome, osteogenesis imperfecta, osteoporosis, Paget's disease of bone–osteitis deformans Diagnostic workup Measure Ca2+, PO4–, PTH, other hormones, bone biopsy, tetracycline test

metabolic bone disease

bone dysmineralization, due to dietary and hormonal dysfunction, e.g. hypercalcaemia, hypocalcaemia, osteoporosis, osteomalacia and rickets, hypoparathyroidism, renal osteodystrophy and Paget's disease

metabolic

pertaining to internal metabolism.

metabolic acidemia
acidemia due to metabolic error.
metabolic bone disease
includes a range of bone diseases associated with metabolic diseases, e.g. secondary hyperparathyroidism, rickets and osteoporosis.
metabolic defect
generally an inherited defect that is present at birth, but which is not necessarily evident clinically for several months afterwards. The defect creates a metabolic error, which leads to the accumulation of end products which cause clinical signs, e.g. mannosidosis, porphyria or an exaggerated response from an end-organ, e.g. inherited goiter. See also inborn error of metabolism.
metabolic diseases
diseases in which normal metabolic processes are disturbed and a resulting absence or shortfall of a normal metabolite causes disease, e.g. hypocalcemia in cows, or an accumulation of the end products of metabolism causes a clinical illness, e.g. acetonemia of dairy cows. Many diseases in this group really have their beginnings in a nutritional deficiency state. See also production diseases.
metabolic encephalopathy
many disorders of metabolism can lead to neurologic abnormalities through alterations in electrolytes and acid-base balance, accumulation of endogenous toxins. See also encephalopathy.
metabolic error
see metabolic defect (above).
metabolic inhibition technique
a virus neutralization test in tissue culture in which phenol-red indicator is used to detect the acid metabolic products of actively metabolizing cells or the lack of metabolism when cells are infected and destroyed by the virus.
metabolic laminitis
metabolic myopathies
muscular dystrophies caused by metabolic defects; include systemic glycogenoses, deposits of a PAS-positive glycoprotein, the lipid storage disease of cats caused by carnitine deficiency.
metabolic pathways
groupings of enzymic processes leading to the synthesis or breakdown of carbohydrates, amino acids and lipids.
metabolic polymyopathy
a muscle disease associated with a metabolic disorder, e.g. hyperadrenocorticism.
metabolic polyneuropathy
a disease of the nerves associated with a metabolic disorder, e.g. uremia, diabetes mellitus or hypothyroidism.
metabolic profile
results of a spectrum of tests of metabolic functions.
metabolic profile test
metabolic rate
the rate of energy metabolism in the body. The basal metabolic rate (BMR) is the rate of energy consumption by the body when it is completely at rest.
metabolic syndrome
characterized by hypertension, insulin resistance, an abnormal plasma lipid profile, and obesity.
metabolic toxins
include histamine, other toxic amines, ketone bodies, phenols and cresols from the large intestine, which are normal end-products of metabolism and indigestion but if their normal excretion and detoxication are impeded, cause intoxication. See also toxin.
metabolic water
the water produced in the body by oxidative metabolism of food; it represents 5-10% of the body's water utilization.
References in periodicals archive ?
Successful high-dose calcium treatment of aluminum-induced metabolic bone disease in longterm home parenteral nutrition.
The contradictory results between our study and previous studies can be explained by demographic differences, the amount of vitamin D, calcium and phosphorus supplements prescription, duration or period of evaluating their impact, and the criteria used to assess metabolic bone disease.
Metabolic bone disease in juvenile Humboldt penguins (Spheniscus humboldti): investigation of ionized calcium, parathyroid hormone, and vitamin [D.
Our findings point to a bimodal age grouping for these fractures: young patients with higher impact trauma and elderly women with cardiovascular and metabolic bone disease.
Epidemiology of metabolic bone disease and clinically related disorders-India, 1963-2001.
People with more severe chronic kidney disease can have a whole host of metabolic bone diseases that mimic osteoporosis, either by bone density criteria or fractures, and yet may not be osteoporosis," said Dr.
Comprehensive, authoritative, and abundantly illustrated and referenced, this resource contains 212 contributed chapters covering the scientific and clinical fundamentals, imaging techniques, principles of management, regional and widespread pain, rheumatoid arthritis and other synovial disorders, pediatric rheumatology, infection-related rheumatic diseases, spondyloarthritis, connective tissue disorders, the vasculitides, osteoarthritis, crystal-related arthropathies, endocrine and hemoglobin-related arthritis, metabolic bone disease, and heritable diseases and tumors of bone and connective tissue.
The sections cover disorders of the upper and lower limb and spine, including anatomy, trauma, and degenerative and acquired disorders, and the basic science of the musculoskeletal system, metabolic bone disease, rheumatologic diseases, musculoskeletal tumors, the sequelae of trauma, and congenital deformities.
Following are seven contributions on topics including metabolic bone disease, tumors, trauma, and congenital anomalies.
For patients with stage 5 CKD who have low BMD or fragility fractures, a double tetracycline-labeled bone biopsy is necessary to rule out other causes of metabolic bone disease and confirm a diagnosis of osteoporosis.
Low bone density is not uncommon in young adults but--at least in the short-term--does not carry with it the same relative risk of fracture as in older individuals unless secondary causes of metabolic bone disease are identified, said Andrew J.