Basal release of
met-enkephalin and neurotensin in the ventrolateral periaqueductal gray matter of the rat: A microdialysis study of antinociceptive circuits.
In turn,
met-enkephalin, leu-enkephalin, [beta]-endorphin, [alpha]-neo-endorphin, dynorphin, and nociceptin/orphanin are opioid peptides.
ACTH, beta-endorphin and
met-enkephalin: peripheral modifications during the stress of human labor.
Individuals genotyped with MET158MET (rs4680) had higher MOR protein expression and lower
met-enkephalin concentrations (54).
Stein, "[beta]-Endorphin,
Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis," Annals of the Rheumatic Diseases, vol.
To determine whether metenkephalin plays a major role in cancer-related pain relief, naloxone was used to reverse the antiallodynic effect due to
met-enkephalin. Thus, naloxone was injected intraperitoneally 30 min after PMWT had been assessed on day 21 after tumor cell inoculation, and PMWT was measured again.
Additionally, IL-33 can influence the production of
met-enkephalin by ILC2s, which can induce the process of "browning" in differentiated adipose cells [10].
Our study used a TENS protocol with a preset frequency of 2 Hz and an intensity of maximal tolerable but short of pain because low frequency high intensity TENS has been reported to induce the release of [beta] endorphin, endomorphin, and
met-enkephalin levels [14].
Recently, it was demonstrated that neurons expressing the dopaminergic receptors were immunopositive for the endogenous opioid
met-enkephalin [3].
While the cold effect in part may be mediated by IL-4 and its receptor IL-4Ra in the adipocyte precursors, in mature adipose cells a reduction in the IL4Ra is observed and probably this effect may include diverse mediators, including IL-33 and
Met-enkephalin [47, 48].
Plasma
Met-enkephalin and catecholamine responses to intense exercise in humans.
Met-enkephalin is one of the simplest endogenous opioid peptides within the enkephaline family.
