met-enkephalin


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met-enkephalin

 [met″en-kef´ah-lin]
see enkephalin.

POMC

A gene on chromosome 2p23 that encodes proopiomelanocortin, the melanocortin family of hormones, which include alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins bind to the melanocortin receptors, a group of five G protein-coupled receptors (MC1R to MC5R) which are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

Molecular pathology
Defects of POMC are associated with susceptibility to obesity and proopiomelanocortin deficiency.
References in periodicals archive ?
Basal release of met-enkephalin and neurotensin in the ventrolateral periaqueductal gray matter of the rat: A microdialysis study of antinociceptive circuits.
In turn, met-enkephalin, leu-enkephalin, [beta]-endorphin, [alpha]-neo-endorphin, dynorphin, and nociceptin/orphanin are opioid peptides.
Individuals genotyped with MET158MET (rs4680) had higher MOR protein expression and lower met-enkephalin concentrations (54).
Stein, "[beta]-Endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis," Annals of the Rheumatic Diseases, vol.
To determine whether metenkephalin plays a major role in cancer-related pain relief, naloxone was used to reverse the antiallodynic effect due to met-enkephalin. Thus, naloxone was injected intraperitoneally 30 min after PMWT had been assessed on day 21 after tumor cell inoculation, and PMWT was measured again.
Additionally, IL-33 can influence the production of met-enkephalin by ILC2s, which can induce the process of "browning" in differentiated adipose cells [10].
Our study used a TENS protocol with a preset frequency of 2 Hz and an intensity of maximal tolerable but short of pain because low frequency high intensity TENS has been reported to induce the release of [beta] endorphin, endomorphin, and met-enkephalin levels [14].
Recently, it was demonstrated that neurons expressing the dopaminergic receptors were immunopositive for the endogenous opioid met-enkephalin [3].
While the cold effect in part may be mediated by IL-4 and its receptor IL-4Ra in the adipocyte precursors, in mature adipose cells a reduction in the IL4Ra is observed and probably this effect may include diverse mediators, including IL-33 and Met-enkephalin [47, 48].
Met-enkephalin is one of the simplest endogenous opioid peptides within the enkephaline family.