The thicknesses of glomerular and tubular basal membranes and the Bowman's capsule increase; podocyte damage occurs, and hyalinisation of afferent and efferent arterioles with hypertrophy in
mesangial cells are encountered.
Light microscopy indicated a proliferation of
mesangial cells and mesangial matrix, with only a minority of tissue samples showing segmental sclerosis.
The irregular
mesangial cells and wrinkling basement membranes were also sevent with pyknotic nuclei and several lysosomes (Figs.
Macrophages and glomerular
mesangial cells can oxidize lipoprotein.
In the glomeruli, this receptor seems to be present in all major renal cells, including
mesangial cells, endothelial cells, and podocytes.
Glomerular global sclerosis was observed in one glomerulus and increased
mesangial cells and matrix, and glomerular hypertrophy in other glomerulus.
Tufts reveal segmental proliferation of
mesangial cells and endocapillar with segmental expansion of mesangial matrix and formation of synechiae.
Immunoglobulin A (IgA) nephropathy is characterized by mesangial IgA deposits and expansion of glomerular mesangial matrix with proliferation of
mesangial cells. Its clinical manifestation is extremely variable, ranging from asymptomatic microscopic hematuria to rapidly progressive renal failure.
For confirmation of the mesangial proliferative glomerulonephritis by inducing ethanol intake and restraint stress, the number of the
mesangial cells was counted in the 65 glomerulus of the kidney.
In the control group, histological sections showed glomeruli with corpuscles containing capillaries,
mesangial cells, and normal matrix, including Bowman's space.
Proliferative
mesangial cells, increased ECM, thickened glomerular basement membrane, and disorderly arranged renal tubular cells were shown in the model group.
Zheng et al., "Transcription factor Egr1 is involved in high glucose-induced proliferation and fibrosis in rat glomerular
mesangial cells," Cellular Physiology and Biochemistry, vol.
