Merkel cell carcinoma


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Merkel cell carcinoma

A highly aggressive skin tumour, usually of the head and neck, which is most common in the elderly, and 13-fold more common in patients with HIV-1. Merkel cell polyomavirus is clonally integrated at various sites in the genome of most Merkel cell carcinomas.

Associations
Actinic keratoses, Bowen's disease, squamous cell carcinoma, basal cell carcinoma.
 
DiffDx
Small blue-cell tumours—e.g., leukaemia, acute lymphoblastic lymphoma, granulocytic sarcoma, NK/T-cell lymphoma, and metastatic small cell carcinoma from the lung or elsewhere.
 
Prognosis
3-year survival: 68% female, 36% male.

Poor prognosticators
> 30 mm tumour, stage II+, lack of inflammation, Ki-67 (cell proliferation) index of > 50%.

Management
Wide excision, prophylactic lymph node dissection, radiation therapy, chemotherapy.

Merkel cell carcinoma

Cutaneous neuroendocrine carcinoma A highly malignant skin tumor, usually head & neck, most common in the elderly Prognosis Poor, 3-yr survival 68% ♀, 36% ♂ Treatment Wide excision, prophylactic LN dissection, RT, chemotherapy

Mer·kel cell car·ci·no·ma

(mĕr'kĕl sel kahr'si-nō'mă)
Rare and highly aggressive skin cancer, with lesions that develop on or just below the skin that are usually found on sun-exposed body areas; appear as painless, firm nodules or tumors; metastasize quickly and spread to other parts of the body, tending toward the regional lymph nodes. Twice as common in older men.
References in periodicals archive ?
Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008; 319:1096-1100.
Merkel cell carcinoma of the gluteal region with ipsilateral metastasis into the pancreatic graft of a patient after combined kidney-pancreas transplantation.
Hodgson, "Merkel cell carcinoma: changing incidence trends," Journal of Surgical Oncology, vol.
Clinicopathological and immunohistochemical analysis of 20 cases of Merkel cell carcinoma in search of prognostic markers.
Merkel cell carcinoma of the head and neck: A single institutional experience.
Markiefka et al., "[sup.68]Ga-DotaTATE PET-CT followed by Peptide Receptor Radiotherapy in combination with capecitabine in two patients with Merkel Cell Carcinoma," International Journal of Clinical and Experimental Medicine, vol.
It's biologically plausible that a patient's vitamin D status influences Merkel cell carcinoma behavior, according to Dr.
They found that patients with Merkel cell carcinoma who had low numbers of lymphocytes-a type of white blood cell that participates in immune function-didn't live as long after treatment as those with higher lymphocyte counts.
(2.) Allen PJ, Bowne WB, Jaques DP et al: Merkel cell carcinoma: prognosis and treatment of patients from a single institution.
Merkel cell carcinoma of the head and neck: Report of seven cases.
Merkel cell carcinoma of the eyelid: review of the literature and report of patients with Merkel cell carcinoma showing spontaneous regression.
The link between skin cancer Merkel cell carcinoma and polyomavirus, which is found in birds but can be caught by humans, was discovered by researchers at Israel's Bar-Ilan University.