Merkel cell carcinoma

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Merkel cell carcinoma

A highly aggressive skin tumour, usually of the head and neck, which is most common in the elderly, and 13-fold more common in patients with HIV-1. Merkel cell polyomavirus is clonally integrated at various sites in the genome of most Merkel cell carcinomas.

Associations
Actinic keratoses, Bowen's disease, squamous cell carcinoma, basal cell carcinoma.
 
DiffDx
Small blue-cell tumours—e.g., leukaemia, acute lymphoblastic lymphoma, granulocytic sarcoma, NK/T-cell lymphoma, and metastatic small cell carcinoma from the lung or elsewhere.
 
Prognosis
3-year survival: 68% female, 36% male.

Poor prognosticators
> 30 mm tumour, stage II+, lack of inflammation, Ki-67 (cell proliferation) index of > 50%.

Management
Wide excision, prophylactic lymph node dissection, radiation therapy, chemotherapy.

Merkel cell carcinoma

Cutaneous neuroendocrine carcinoma A highly malignant skin tumor, usually head & neck, most common in the elderly Prognosis Poor, 3-yr survival 68% ♀, 36% ♂ Treatment Wide excision, prophylactic LN dissection, RT, chemotherapy

Mer·kel cell car·ci·no·ma

(mĕr'kĕl sel kahr'si-nō'mă)
Rare and highly aggressive skin cancer, with lesions that develop on or just below the skin that are usually found on sun-exposed body areas; appear as painless, firm nodules or tumors; metastasize quickly and spread to other parts of the body, tending toward the regional lymph nodes. Twice as common in older men.
References in periodicals archive ?
But in a few people, the infection gives rise to Merkel cell cancer, a rare, aggressive malignancy that commonly involves the skin, but can subsequently metastasize to lymph nodes and other organs.
Second, the initial histopathologic diagnosis of this tumor was as a Merkel cell cancer (MCC) of the vagina.
This protein is commonly found in transitional cell cancer, colorectal cancer and merkel cell cancer. Anti-Cytokeratin 20 is useful in the differentiation of specific types of simple epithelial cells of the urinary tract as well as normal and malignantly transformed epithelia.
Economopoulos, "Merkel cell cancer of the skin," Annals of Oncology, vol.
Pathological and radiological differential diagnosis Small round blue cell tumour Radiological Non-Hodgkin's lymphoma Rhabdomyosarcoma Rhabdomyosarcoma Myosarcoma Small cell lung cancer Malignant fibrous Merkel cell cancer histiocytoma (MFH) Haemangiopericytoma Dedifferentiated liposarcoma Neuroblastoma Ewing's sarcoma Ewing's sarcoma Primitive neuro-ectodermal tumour (PNET) In our patients, the radiological CT observed bony changes in the first case were not in keeping with a primary bony neoplasm and thought to be reactive change secondary to the large associated soft-tissue tumor, confirming an ESS.
Contributions in James's memory can be given to Merkel Cell Cancer Research, by going to its website www.merkelcell.org.
A punch biopsy was performed, and the initial diagnosis was Merkel cell cancer. Two months later, a follow-up examination revealed a 1-cm-by-l-cm raised nodular mass in his left groin, surrounded by a 10-[cm.sup.2] area identified as "candidiasis." Dermatology was consulted.
Although pioneered in the fields of skin and breast cancer, lymphatic mapping and sentinel lymph node biopsy have since been explored in Merkel cell cancer and cancers of the head and neck, stomach, colon, esophagus, anus, thyroid, penis, and vulva, Dr.