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Related to Meridia: phentermine, Xenical, sibutramine


A central, appetite-suppressing agent that blocks reuptake of serotonin, norepinephrine and, to a lesser extent, dopamine; it provides a sensation of fullness from lesser amounts of food, and increases metabolism. Sibutramine was approved for use as a dietary adjunct in the mid-1990s and was heavily marketed until 2010, when it was withdrawn from the market due to the increased risk of cardiovascular events and strokes associated with its use. Sibutramine is a Schedule-IV Controlled Substance.

Obese patients with an initial BMI of ≥ 30 kg/m2 or ≥ 27 kg/m2 in addition to other factors (e.g., hypertension, diabetes, dyslipidemia).

Adverse effects
Headache, dry mouth, anorexia, constipation.

Concurrent MAOIs, other central appetite suppressants, anorexia nervosa.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Sibutramine Obesity An anti-obesity agent used to facilitate and maintain weight loss, coupled to a low-calorie diet Contraindications Hx of stroke, CAD, CHF, uncontrolled HTN. See Obesity. Cf Xenical.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Meridia Metro is situated at the intersection of State and Warren Streets proximate to Routes 4 and 17 and Interstate 80.
Some fixes have been noted on patch version 1.1.2 such as for the Army of Meridia and A Walk Above the Clouds quests.
For example, the FDA warned last October that 20 brands of dietary supplements for weight loss were tainted with sibutramine--the active ingredient in prescription weight-loss drug Meridia that was linked to elevated blood pressure, heart rhythm problems, heart attacks, and stroke and removed from the U.S.
The agency also asked Abbott Laboratories to withdraw its diet medicine, Meridia, from the market due to heart risks, and the company agreed.
In the past year, the FDA has evaluated three new weight loss drugs (Qnexa, lorcaserin and Contrave) one old weight loss drug (Meridia), and the expanded use of a specific weight loss surgery (Lap-Band).
But if you plan to use a diet drug to achieve your goal, hear this: A study reported in the September 1, 2010, New England Journal of Medicine found that overweight patients with cardiac risk factors and /or type 2 diabetes who took the weight-loss drug sibutramine (Meridia) actually increased their risk of heart attack and stroke 16 percent, even when they followed a diet-and-exercise program (Note: Meridia was taken off the market in October 2010.) The likely reason is that sibutramine increases blood pressure and resting pulse rate, both of which increase the risk of heart attack or stroke.
Among the illegally marketed products are those containing drugs that have been withdrawn from the market for safety reasons, including the weight-loss drugs sibutramine (Meridia) and fenfluramine.
Safety concerns have doomed previous weight-loss drugs, including Abbott Laboratories Inc.'s Meridia, which was pulled off the market in October because of heart risks.
The weight-loss drug sibutramine (Meridia) has been withdrawn from the U.S.
The FDA's reversal on Menaflex, together with its decision to withdraw the obesity drug sibutramine (Meridia; Abbott Laboratories) from the market at around the same time, demonstrates that the agency is more militant about patient safety than it had been during President Bush's administration, said Diana Zuckerman, Ph.D., president of the nonpartisan National Research Center for Women and Families, a Washington, D.C.-based group that specializes in health issues.
"Physicians are advised to stop prescribing Meridia to their patients," Dr.
take Meridia[R] and that it requested Meridia's withdrawal because the "very modest weight loss" from taking the drug didn't justify its risk of heart attack or stroke.