MIF

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MIF

 [mif]

MIF

Abbreviation for migration-inhibitory factor.

MIF

A gene on chromosome 22q11.23 that encodes macrophage migration inhibitory factor (MMIF), a proinflammatory lymphokine involved in innate cell-mediated immunity, immunoregulation and inflammation, which regulates macrophage function in host defence by suppressing the anti-inflammatory effects of glucocorticoids.

Molecular pathology
Genetic variations of MIF have been linked to an increase in susceptibility to juvenile rheumatoid arthritis.