(byoo-ten-a-feen) ,

Lotrimin Ultra

(trade name),


(trade name)


Therapeutic: antifungals
Pregnancy Category: B


Treatment of a variety of cutaneous fungal infections, including tinea pedis (athlete’s foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea versicolor.


Affects the synthesis of the fungal cell wall.

Therapeutic effects

Decrease in symptoms of fungal infection.


Absorption: Absorption through intact skin is minimal.
Distribution: Distribution after topical administration is primarily local.
Metabolism and Excretion: Hepatic via hydroxylation.
Half-life: 35 hr.

Time/action profile

Topunknownup to 4 wkunknown


Contraindicated in: Hypersensitivity to active ingredients, additives, preservatives, or bases; Some products contain alcohol or bisulfites and should be avoided in patients with known intolerance.
Use Cautiously in: Nail and scalp infections (may require additional systemic therapy); Obstetric / Lactation: Safety not established.

Adverse Reactions/Side Effects


  • burning
  • itching
  • local hypersensitivity reactions
  • redness
  • stinging


Drug-Drug interaction

None significant.


Topical (Adults and Children > 12 yr) Apply once daily for 2 wk for patients with tinea corporis, tinea cruris, or tinea versicolor. Apply once daily for 4 wk or twice daily for 7 days for patients with tinea pedis.


Cream: 1%Rx, OTC

Nursing implications

Nursing assessment

  • Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.

Potential Nursing Diagnoses

Risk for impaired skin integrity (Indications)
Risk for infection (Indications)


  • Consult physician or other health care professional for proper cleansing technique before applying medication.
  • Topical: Apply small amount to cover affected area completely. Avoid the use of occlusive wrappings or dressings unless directed by physician or other health care professional.

Patient/Family Teaching

  • Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes or vaginal area.
  • Caution patient that some products may stain fabric, skin, or hair. Check label information. Fabrics stained from cream can usually be cleaned by handwashing with soap and warm water.
  • Patients with athlete’s foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
  • Advise patient to report increased skin irritation or lack of response to therapy to health care professional.
  • Early relief of symptoms may be seen in 2–3 days. For tinea cruris, tinea corporis, and tinea versicolor, 2 wk are needed, and for tinea pedis, therapeutic response may take 4 wk. Recurrent fungal infections may be a sign of systemic illness.

Evaluation/Desired Outcomes

  • Decrease in skin irritation and.
  • Resolution of infection.
Drug Guide, © 2015 Farlex and Partners


Butenafine Dermatology An antifungal for tinea corporis, tinea cruris, interdigital tinea pedis, onychomycosis. See Dermatophytosis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Butenafine (Mentax), a benzylamine antifungal, was 88% to 93% mycologically effective in a noncomparative study, when used twice daily for 2 weeks.
Three Penederm products that are already on the market will also come under the umbrella of Mylan: Acticin, an antiscabies treatment; Avita, an antiacne therapy, and Mentax, an antifungal.
TABLE RECOMMENDED TOPICAL TREATMENTS FOR TINEA PEDIS Cure Frequency Bates, and duration Drug % Form of treatment * Comments Miconazole 47 2% lotion, BID for 2-4 Inexpensive, (Micatin) spray, weeks OTC cream, powder Terbinafine 70 1% cream, BID for 1-2 Shorter length (Lamisil) solution, weeks of treatment, spray OTC Naftifine 70 1% gel, QD for 2-4 Once a day, Rx (Naftin) cream weeks Butenafine 70 1% cream QD for 4 Once a day, Rx (Mentax) weeks Tolnaftate 64 1% powder, BID for 2-4 Inexpensive, (Tinactin, spray, cream weeks OTC Altate) Rx denotes prescription; OTC, over the counter; BID, twice a day; QD, every day.