membrane transport protein

(redirected from Membrane transporter)

membrane transport protein

a PROTEIN that can transport specific MOLECULES across MEMBRANES which would otherwise not be permeable to them.
References in periodicals archive ?
The company's product candidates target disease tissues via a novel antibody with cell-penetrating properties dependent on a tissue-localized membrane transporter.
In particular, animals treated with amphetamine develop lasting reductions in striatal dopamine, its major metabolite dihydroxyphenylacetic acid (DOPAC), its rate-limiting enzyme tyrosine hydroxylase, its membrane transporter (DAT), and its vesicular transporter (VMAT2) (Gibb et al.
Overexpression of P-glycoprotein (P-gp), an ATP-binding cassette (ABC) membrane transporter, can mediate the efflux of cytotoxic drugs out of cancer cells, leading to MDR and chemotherapy failure.
Developed by researchers at drug manufacturer Ardelyx, the drug, tenapanor, works by blocking a membrane transporter called NH3, which is responsible for most of the reuptake of sodium in the body.
Third type of ionic movement is performed by membrane transporter proteins such as ABC transport proteins (Table 5) 35].
We discovered that natural folate is brought into and metabolized in a tumor cell via a plasma membrane transporter, and that this is the same route of entry that tumor cells use to bring in methotrexate," explained Dr.
In wheat, aluminum tolerance is regulated by a membrane transporter encoded by the aluminum-tolerance gene ALTM1.
Induction or inhibition of membrane transporter proteins (e.
The peripheral iodide enters the thyrocyte via the symporter in the basal membrane and crosses the thyrocyte as iodide to exit the thyrocyte via the apical membrane transporter just prior to oxidation and organification.
Energy-dependent efflux of macrolides from target cells by a cell membrane transporter has been associated with the presence of mef genes.
In 1993, a strategy for locating and cloning membrane transporter proteins was devised by Dr Frank Smith's research group at CSIRO Tropical Agriculture and British scientists at the Long Ashton Research Station at Bristol.
Transporter sciences study membrane transporter proteins and their roles in (patho)physiology and pharmacology.

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