membrane transport protein

(redirected from Membrane transporter)

membrane transport protein

a PROTEIN that can transport specific MOLECULES across MEMBRANES which would otherwise not be permeable to them.
References in periodicals archive ?
The new insights into its structure may also provide clues as to how this family of transporters bind other diverse peptides -- important information as a similar membrane transporter is used in humans for intestinal absorption of drugs in our small intestines."
The work horses for detoxification are 1) MRP1, the transmembrane transporter serving most cells in the body for exporting toxins to circulation, 2) OATP, the basolateral membrane transporter which moves toxin conjugates from the blood into the hepatocytes or renal tubule epithelial cells, and 3) MRP2, the apical transporter that moves toxin conjugates (and some bile salts) into the bile canaliculus or renal proximal tubule lumen.
Eyal, "Molecular imaging of membrane transporter activity in cancer: a picture is worth a thousand tubes," AAPS Journal, vol.
In particular, animals treated with amphetamine develop lasting reductions in striatal dopamine, its major metabolite dihydroxyphenylacetic acid (DOPAC), its rate-limiting enzyme tyrosine hydroxylase, its membrane transporter (DAT), and its vesicular transporter (VMAT2) (Gibb et al., 1994; McCann and Ricaurte, 2004). Anatomic studies indicate that lasting dopaminergic deficits after amphetamine are due to damage of dopaminergic nerve endings in the striatum, with sparing of dopaminergic nerve cell bodies in the substantia nigra.
Overexpression of P-glycoprotein (P-gp), an ATP-binding cassette (ABC) membrane transporter, can mediate the efflux of cytotoxic drugs out of cancer cells, leading to MDR and chemotherapy failure.
Developed by researchers at drug manufacturer Ardelyx, the drug, tenapanor, works by blocking a membrane transporter called NH3, which is responsible for most of the reuptake of sodium in the body.
According to RAST annotation, the CDSs encode proteins including membrane fusion protein CmeA, inner membrane transporter CmeB, and outer membrane lipoprotein CmeC (Figure 3).
Iwase et al., "Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria," Pharmaceutical Research, vol.
"We discovered that natural folate is brought into and metabolized in a tumor cell via a plasma membrane transporter, and that this is the same route of entry that tumor cells use to bring in methotrexate," explained Dr.
In wheat, aluminum tolerance is regulated by a membrane transporter encoded by the aluminum-tolerance gene ALTM1.
Induction or inhibition of membrane transporter proteins (e.g.
Energy-dependent efflux of macrolides from target cells by a cell membrane transporter has been associated with the presence of mef genes.

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