lipid raft

(redirected from Membrane microdomains)

lipid raft

(lip'id raft),
Detergent-insoluble raft microdomains that are enriched in sphingolipids and cholesterol, found in the plasma membrane, late secretory pathway, and endosomal compartments.

lipid raft

A tiny cholesterol-rich region on a cell membrane that helps selected molecules enter the cytoplasm.
Synonym: lipid domain
See also: raft
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References in periodicals archive ?
In cell membranes, sphingolipids are associated with sterols to form specialized plasma membrane microdomains called lipid rafts that facilitate ligand-receptor interaction, cellular signal transduction, and membrane protein trafficking [23, 24].
Krautkramer et al., "Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains," Retrovirology, vol.
However, I have discovered that bacteria organize many signaling pathways in membrane microdomains similar to the eukaryotic lipid rafts.
The membrane lipid rafts are cholesterol- and sphingomyelin-rich membrane microdomains and indicate an important feature that may contribute to signalings through the plasma membrane.
Considering the documented effects on membrane microdomains in these systems (Gil et al..
Studies of cholesterol-rich membrane microdomains (rafts) are of great interest for biomedical applications.
Psychosine accumulates in membrane microdomains in the brain of Krabbe patients, disrupting the raft architecture.
Both of these lipids are possibly enriched in lipid rafts or membrane microdomains distinct from sphingolipid-rich domains.
The archaeal cholesterol catabolism can deplete the lymphocytic cell membranes of cholesterol resulting in alteration of lymphocytic cell membrane microdomains related receptors producing immune activation.
Assembly of staphylococcal leukocidin into a pore-forming oligomer on detergent-resistant membrane microdomains, lipid rafts, in human polymorphonuclear leukocytes.
Background and Significance: Lipid rafts are cholesterol rich membrane microdomains that bring innate immune receptors like Toll like receptor (TLR) together with signaling molecules like Src family tyrosine kinases to transmit the extracellular events into the cytoplasmic cascade of signaling proteins activation.

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