lipid raft

(redirected from Membrane microdomains)

lipid raft

(lip'id raft),
Detergent-insoluble raft microdomains that are enriched in sphingolipids and cholesterol, found in the plasma membrane, late secretory pathway, and endosomal compartments.

lipid raft

A tiny cholesterol-rich region on a cell membrane that helps selected molecules enter the cytoplasm.
Synonym: lipid domain
See also: raft
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References in periodicals archive ?
However, I have discovered that bacteria organize many signaling pathways in membrane microdomains similar to the eukaryotic lipid rafts.
Considering the documented effects on membrane microdomains in these systems (Gil et al.
Psychosine accumulates in membrane microdomains in the brain of Krabbe patients, disrupting the raft architecture.
Both of these lipids are possibly enriched in lipid rafts or membrane microdomains distinct from sphingolipid-rich domains.
The archaeal cholesterol catabolism can deplete the lymphocytic cell membranes of cholesterol resulting in alteration of lymphocytic cell membrane microdomains related receptors producing immune activation.
Assembly of staphylococcal leukocidin into a pore-forming oligomer on detergent-resistant membrane microdomains, lipid rafts, in human polymorphonuclear leukocytes.
Background and Significance: Lipid rafts are cholesterol rich membrane microdomains that bring innate immune receptors like Toll like receptor (TLR) together with signaling molecules like Src family tyrosine kinases to transmit the extracellular events into the cytoplasmic cascade of signaling proteins activation.
This issue will be investigated on subcellular level, within given cellular compartments and membrane microdomains using the combination of biochemical methods with superresolution microscopy on mammalian cells.
The archaeal cholesterol catabolism can deplete the lymphocytic cell membranes of cholesterol resulting in alteration of cell membrane microdomains related to oncogenic cell growth factors protein tyrosine kinase receptors and AKT PI3K producing cell proliferation and malignant transformation.
We have also demonstrated the preferential phosphorylation of DATs within these membrane microdomains.
Lipid rafts are heterogeneous, small (10-200nm) membrane microdomains that are enriched cholesterol and serve as a signaling platform for a multitude of cellular processes.

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