However, I have discovered that bacteria organize many signaling pathways in membrane microdomains
similar to the eukaryotic lipid rafts.
Considering the documented effects on membrane microdomains
in these systems (Gil et al.
Psychosine accumulates in membrane microdomains
in the brain of Krabbe patients, disrupting the raft architecture.
Both of these lipids are possibly enriched in lipid rafts or membrane microdomains
distinct from sphingolipid-rich domains.
The archaeal cholesterol catabolism can deplete the lymphocytic cell membranes of cholesterol resulting in alteration of lymphocytic cell membrane microdomains
related receptors producing immune activation.
Lipid rafts and little caves: compartmentalized signalling in membrane microdomains
Assembly of staphylococcal leukocidin into a pore-forming oligomer on detergent-resistant membrane microdomains
, lipid rafts, in human polymorphonuclear leukocytes.
Background and Significance: Lipid rafts are cholesterol rich membrane microdomains
that bring innate immune receptors like Toll like receptor (TLR) together with signaling molecules like Src family tyrosine kinases to transmit the extracellular events into the cytoplasmic cascade of signaling proteins activation.
This issue will be investigated on subcellular level, within given cellular compartments and membrane microdomains
using the combination of biochemical methods with superresolution microscopy on mammalian cells.
The archaeal cholesterol catabolism can deplete the lymphocytic cell membranes of cholesterol resulting in alteration of cell membrane microdomains
related to oncogenic cell growth factors protein tyrosine kinase receptors and AKT PI3K producing cell proliferation and malignant transformation.
We have also demonstrated the preferential phosphorylation of DATs within these membrane microdomains
Lipid rafts are heterogeneous, small (10-200nm) membrane microdomains
that are enriched cholesterol and serve as a signaling platform for a multitude of cellular processes.