Melnick-Needles osteodysplasty

Melnick-Needles osteodysplasty

(mel'nick nē'dĕlz), [MIM*309350]
a generalized skeletal dysplasia with prominent forehead and small mandible; radiographically, there are irregular ribbonlike constrictions of the ribs and tubular bones; probably X-linked [MIM*309350]. Autosomal dominant and recessive inheritance [MIM*249420] have also been suggested.
Farlex Partner Medical Dictionary © Farlex 2012

Melnick-Needles syndrome

A severe X-linked bone disorder (OMIM:309350) characterised by a typical facies: exophthalmos, full cheeks, micrognathia, malalignment of teeth, flaring of the metaphyses of long bones, bowing of legs, irregular constrictions in the ribs, and sclerosis of the base of skull.

Molecular pathology
Gain-of-function mutations in FLNA, which encodes filamin A, cause Melnick-Needles syndrome.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Mel·nick-Nee·dles os·te·o·dys·plas·ty

(melnik nēdĕlz ostē-ō-dis-plastē)
A generalized skeletal dysplasia with prominent forehead and small mandible; radiographically, there are irregular ribbonlike constrictions of the ribs and tubular bones; probably X-linked. Autosomal dominant and recessive inheritance have also been suggested.
Synonym(s): osteodysplasty.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Mel·nick-Nee·dles os·te·o·dys·plas·ty

(melnik nēdĕlz ostē-ō-dis-plastē) [MIM*309350]
A generalized skeletal dysplasia with prominent forehead and small mandible.
Synonym(s): osteodysplasty.
Medical Dictionary for the Dental Professions © Farlex 2012