Aquaglyceroporin 2 controls susceptibility to melarsoprol
and pentamidine in African trypanosomes.
evansi se basa en farmacos antiprotozoarios como suramina, diaminazina aceturato, quinapiramina, melarsoprol
e isometamidium (18).
and pentamidine were also included in Table 1.
Risk factors for encephalopathy and mortality during melarsoprol
treatment of Trypanosoma brucei gambiense sleeping sickness.
has a low solubility in water, it is dissolved in propylene glycol and administered intravenously.
Because it was not immediately available at the treating hospital, the therapeutic antiprotozoal agent Melarsoprol
(use is described below) was ordered from an outlying area.
For the treatment of East African sleeping sickness, only suramin and melarsoprol
are used in the first and second stage of the disease, respectively.
In many regions, for instance, first-choice therapy for late-stage human African trypanosomiasis (HAT, or sleeping sickness) is still based on melarsoprol
, an arsenic-derived drug developed in the late 19th century that can lead to fatal encephalopathy in 5% of patients.
(8), (9) Los farmacos que se usan en este caso son la pentamidina (4), el melarsoprol
(5) y el megazol (6).
A preliminary comparative study on the efficacy of quinapyramine sulphate/chloride and melarsoprol
in rats, experimentally infected with Trypanosoma evansi.
Advanced cases have been treated with melarsoprol
WHO-recommended treatment with melarsoprol