melarsoprol


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Related to melarsoprol: Nifurtimox, Suramin, Eflornithine

melarsoprol

 [mel-ahr´so-prol]
an antiprotozoal agent effective against trypanosomes.

melarsoprol

An older arsenical used to treat trypanosomiasis caused by Trypanosoma cruzi (Chagas disease) and T brucei gambiense (which causes 95% of cases of sleeping sickness).

Adverse effects
Arsenic poisoning, convulsions, loss of consciousness, rash, fever, nausea, vomiting, bloody stool; treatment-related fatalities are not uncommon. Pentamidine is the drug of choice for first-stage T brucei gambiense infection. Other agents (suramin, eflornithine and nifurtimox) are available in the US from the Centers for Disease Control and Prevention (CDC).

melarsoprol

A combination of melarsan oxide and dimercaprol used to treat TRYPANOSOMIASIS. The drug is highly effective but must be used with caution because of sometimes dangerous side effects including the JARISCH-HERXHEIMER REACTION. The drug is on the WHO official list.
References in periodicals archive ?
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.
evansi se basa en farmacos antiprotozoarios como suramina, diaminazina aceturato, quinapiramina, melarsoprol e isometamidium (18).
Risk factors for encephalopathy and mortality during melarsoprol treatment of Trypanosoma brucei gambiense sleeping sickness.
Because melarsoprol has a low solubility in water, it is dissolved in propylene glycol and administered intravenously.
Because it was not immediately available at the treating hospital, the therapeutic antiprotozoal agent Melarsoprol (use is described below) was ordered from an outlying area.
For the treatment of East African sleeping sickness, only suramin and melarsoprol are used in the first and second stage of the disease, respectively.
In many regions, for instance, first-choice therapy for late-stage human African trypanosomiasis (HAT, or sleeping sickness) is still based on melarsoprol, an arsenic-derived drug developed in the late 19th century that can lead to fatal encephalopathy in 5% of patients.
(8), (9) Los farmacos que se usan en este caso son la pentamidina (4), el melarsoprol (5) y el megazol (6).
A preliminary comparative study on the efficacy of quinapyramine sulphate/chloride and melarsoprol in rats, experimentally infected with Trypanosoma evansi.
Advanced cases have been treated with melarsoprol or eflornithine.
WHO-recommended treatment with melarsoprol was started.