melarsoprol(redirected from Melarsen Oxide-BAL)
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an antiprotozoal agent effective against trypanosomes.
melarsoprolAn older arsenical used to treat trypanosomiasis caused by Trypanosoma cruzi (Chagas disease) and T brucei gambiense (which causes 95% of cases of sleeping sickness).
Arsenic poisoning, convulsions, loss of consciousness, rash, fever, nausea, vomiting, bloody stool; treatment-related fatalities are not uncommon. Pentamidine is the drug of choice for first-stage T brucei gambiense infection. Other agents (suramin, eflornithine and nifurtimox) are available in the US from the Centers for Disease Control and Prevention (CDC).