MC1R

(redirected from Melanocortin-1 receptor)

MC1R

A gene on chromosome 16q24.3 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase.

Molecular pathology
Genetic variations in MC1R are associated with variation in skin/hair/eye pigmentation type 2, and are linked to cutaneous malignant melanoma type 5.
References in periodicals archive ?
Together, they found that opsin 3 changes the activity of the melanocortin-1 receptor, a protein known to increase synthesis of cyclic adenosine monophosphate (cAMP), a molecular signal that triggers melanin production.
Palatin announced a poster presentation on its PL-8177 and PL-8331 melanocortin-1 receptor agonist programs.
The MC1R gene is the melanocortin-1 receptor, which is found on chromosome 16 and causes low concentrations of eumalanin throughout the body.
Muscat, "Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells," The Journal of Biological Chemistry, vol.
The E locus encodes for the melanocortin-1 receptor (MCIR), a transmembrane protein with seven domains belonging to the G protein-coupled membrane receptors, and localizes on the surface of the melanocyte membrane [7].
Peterli, "Expression and localization of melanocortin-1 receptor in human adipose tissues of severely obese patients," Obesity, vol.
Previous research had shown that the melanocortin-1 receptor (MC1R) gene plays a key role in protecting melanocytes from UV-induced DNA damage.
Gallet et al., "A first genotyping assay of french cattle breeds based on a new allele of the extension gene encoding the melanocortin-1 receptor (MC1R)," Genetics Selection Evolution, vol.
The final stage of scientific sanctification is achieved when a plausible biological mechanism is found--a malfunctioning variant of the melanocortin-1 receptor gene is discovered to be an important cause of red hair, and this might be mysteriously linked to opioid receptor malfunction (4).
DENVER -- Identification of individuals possessing certain melanocortin-1 receptor gene variants may aid in detection of those at increased risk of melanoma.
DENVER -- Identification of individuals possessing certain melanocortin-1 receptor gene variants may provide added value in detecting increased risk of melanoma.
The researchers focused their study on one of the key genes that controls coat colour in animals, known as melanocortin-1 receptor (MC1R).