MC1R

(redirected from Melanocortin receptor 1)

MC1R

A gene on chromosome 16q24.3 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase.

Molecular pathology
Genetic variations in MC1R are associated with variation in skin/hair/eye pigmentation type 2, and are linked to cutaneous malignant melanoma type 5.
References in periodicals archive ?
Melanocortin receptor 1 (MC1R) mutations and coat color in pigs.
Polymorphisms in melanocortin receptor 1 gene in goat breeds: a window for coat color controling mechanism.
PL-8177 is a patented melanocortin receptor 1 agonist with potential application in treatment of ulcerative colitis and other inflammatory bowel diseases.
M2 PHARMA-February 7, 2018-Palatin Technologies Doses First Human Subjects in Clinical Study of Investigational Melanocortin Receptor 1 Agonist for Treatment of Inflammatory Bowel Diseases
(NYSE American: PTN) has dosed the first healthy subjects in a Phase 1 clinical study of PL-8177, a selective melanocortin receptor 1 (MC1r) agonist peptide for the treatment of ulcerative colitis and other inflammatory bowel diseases, the company said.
However, it is probable that dysregulation of cell cycle progression, apoptosis, cell-to-cell interactions, cKit signalling pathways, melanocortin receptor 1 (MC1R) polymorphism, melanin itself, and products of melanin biosynthesis are all risk factors (Figure 1).
Global Markets Direct's, 'Melanocyte-Stimulating Hormone Receptor (Melanocortin Receptor 1 or MC1-R or MC1R or MSHR) - Pipeline Review, H1 2016', provides in depth analysis on Melanocyte-Stimulating Hormone Receptor (Melanocortin Receptor 1 or MC1-R or MC1R or MSHR) targeted pipeline therapeutics.
Palatin Technologies announced Phase 1, first-in-human results of a single and multiple ascending-dose study of PL-8177, a patented melanocortin receptor 1 agonist with the potential application of treating ulcerative colitis and other inflammatory diseases.
Melanocortin receptor 1 (MC1R) and its peptide antagonist agouti signaling protein (ASIP) are two major genetic determinants of pigment phenotype in mammals [1,4,5].
The E locus encodes the melanocortin receptor 1 (MC1R), which is a seven-transmembrane domains protein belonging to the G-protein coupled receptor present on the surface of the melanocyte membrane [4].
Palatin Technologies announced the presentation of a poster on preclinical studies of an oral formulation of PL-8177, a selective melanocortin receptor 1 agonist peptide.
A study on genotyping frequencies of the bovine melanocortin receptor 1 (MC1R) in cattle breeds.