melanocortin 4 receptor

Also found in: Acronyms.


A gene on chromosome 18q22 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase and expressed in the brain, placenta and gut.

Molecular pathology
Defects in MC4R are linked to obesity.

melanocortin 4 receptor (MC4R)

A cell receptor that is strongly stimulated by the alpha melanocyte-stimulating hormone-a peptide that produces a sense of fullness after eating. Mutations of the gene that codes for MC4R are commonly associated with severe uncontrollable overeating and pathological obesity. Such mutations can be found in nearly 6 per cent of people with a life-long history of obesity.
References in periodicals archive ?
A melanocortin 4 receptor (MC4R) polmorphism is associated with performance traits in divergently selected large white pigs populations.
Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs.
In the future, drugs that mimic the melanocortin 4 receptor protein may compensate for the defective gene.
Rhythm, a biopharmaceutical company, has started two Phase 2 clinical trials focused on assessing the safety and effectiveness of setmelanotide, the company's novel melanocortin 4 receptor (MC4R) agonist for the treatment of Prader-Willi Syndrome and POMC-null obesity, it was reported on Friday.
One of these is the melanocortin 4 receptor (MC4-R), which Barsh believes is switched off by AGRP.