melanocortin 4 receptor


Also found in: Acronyms.

MC4R

A gene on chromosome 18q22 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase and expressed in the brain, placenta and gut.

Molecular pathology
Defects in MC4R are linked to obesity.

melanocortin 4 receptor (MC4R)

A cell receptor that is strongly stimulated by the alpha melanocyte-stimulating hormone-a peptide that produces a sense of fullness after eating. Mutations of the gene that codes for MC4R are commonly associated with severe uncontrollable overeating and pathological obesity. Such mutations can be found in nearly 6 per cent of people with a life-long history of obesity.
References in periodicals archive ?
About RM-493 RM-493 is a small-peptide melanocortin 4 receptor (MC4R) agonist that is in clinical development for the treatment of obesity and diabetes.
4, 2013 /PRNewswire/ -- Rhythm announced today the initiation of a Phase 2 clinical trial with RM-493, the company's novel melanocortin 4 receptor (MC4R) agonist, for the treatment of obesity.
RM-493 is a melanocortin 4 receptor (MC4R) agonist that is completing Phase 1 clinical trials for the treatment of obesity and diabetes.
Rhythm is developing RM-131, a small-peptide ghrelin agonist, for the treatment of gastrointestinal functional disorders; and RM-493, a small-peptide melanocortin 4 receptor (MC4R) agonist, for the treatment of obesity and diabetes.
RM-493 is a novel peptide agonist targeting the melanocortin 4 receptor (MC4R) that is a clinical candidate for the treatment of obesity and diabetes.