Megatrial

A massive randomized clinical trial that tests the advantages of marginally effective experimental drugs by enrolling 10,000 or more subjects
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20) However, it is not likely that the courts in that state, or any other, would ever again order up such a megatrial, and so another anecdotal reason for changing the law seems more historical than current.
That was the key message of ONTARGET (the Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial), a 25,620-patient megatrial presented by Dr.
The MGM Grand Hotel insurance megatrial ended Wednesday at the Thomas and Mack Center in a festive mood, as District Judge Paul Goldman approved the $87.
NEW ORLEANS -- No sooner had the ink dried on new American College of Physicians practice guidelines calling for ACE inhibitor therapy in patients with coronary artery disease than the document was rendered outdated by a new megatrial.
ATLANTA -- Antibiotic therapy for prevention of coronary events has proved to be a washout in its first megatrial.
Results of the Heart Protection Study, the latest blockbuster statin trial, will likely transform the landscape of medical practice, observers agreed after initial presentation of the British megatrial at the annual scientific sessions of the American Heart Association.
The a-blocker arm of a landmark megatrial of antihypertensive therapy has been halted early due to sharp increases in congestive heart failure and stroke.
BARCELONA, SPAIN -- Fibrinolytic primacy in acute MI reperfusion therapy will give way to combined therapy that focuses on platelets as well as fibrin after the results of a new megatrial are released later this fall.
We were involved in some of the earliest global megatrials, as they were called.
One thing's clear looking out at the research horizon: Megatrials enrolling tens of thousands of patients to answer key clinical questions are not a thing of the past--far from it.